RESUMEN
Clinical and bacteriological effectiveness of two regimes of dosages of ceftazidime and amikacine in patients with ventilator-associated pneumonia (VAP) was evaluated. Patients were divided into two groups. 1A group--19 patients recieving antibacterial treatment for VAP where we used combination of ceftazidime 2 g i.v. 3 times a day and amikacine 500 mg i.v. 2 times a day. 1B group--21 patients who have had a combination therapy of ceftazidime and amikacine in changed regimes of dosages. The loaded dose of ceftazidime bolus was 2 g i.v., then permanent infusion 3g per day. The dose of amikacine was 15 mg/kg per day once a day. The use of cephalosporins of the III-d generation and aminoglycosides in the high dosage is one of the possible safe forms to increase the effectiveness of antibacterial therapy in the treatment of nosocominal infection in the condition of polyresistent flora.
Asunto(s)
Amicacina/administración & dosificación , Antibacterianos/administración & dosificación , Ceftazidima/administración & dosificación , Infección Hospitalaria/tratamiento farmacológico , Quimioterapia Combinada , Bacterias Grampositivas/efectos de los fármacos , Neumonía Asociada al Ventilador/tratamiento farmacológico , Adolescente , Adulto , Infección Hospitalaria/microbiología , Vías de Administración de Medicamentos , Esquema de Medicación , Farmacorresistencia Bacteriana Múltiple , Femenino , Bacterias Grampositivas/crecimiento & desarrollo , Humanos , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Neumonía Asociada al Ventilador/microbiología , Resultado del Tratamiento , Uzbekistán , Adulto JovenRESUMEN
The echinococcal immunosuppression induced in experimental mice by a human parasite strain is accompanied by immunosuppression, whereby the administration of immunomodulants favors normalization of the cell and humoral immunity chains. Among a series of preparations studied, the best results were obtained for polyoxidonium: in the case of immunosuppression induced by cyclophosphan, polyoxidonium administration led normalization of the cell and humoral immunity and the phagocytosis of neutrophils and macrophages.
Asunto(s)
Adyuvantes Inmunológicos/farmacología , Equinococosis/inmunología , Animales , Formación de Anticuerpos , Ciclofosfamida/toxicidad , Humanos , Tolerancia Inmunológica , Inmunidad Celular , Masculino , Ratones , Fagocitosis/efectos de los fármacosAsunto(s)
Estrofantidina/uso terapéutico , Glicósidos Cardíacos/uso terapéutico , Enfermedad Coronaria/tratamiento farmacológico , Enfermedad Coronaria/fisiopatología , Evaluación de Medicamentos , Femenino , Hemodinámica/efectos de los fármacos , Humanos , Hipertensión/tratamiento farmacológico , Hipertensión/fisiopatología , Masculino , Persona de Mediana EdadRESUMEN
Lengthening of the N-alkyl radical (from--C2H5 to C10H21) in the series of polymethylene-bis-quaternary ammonium compounds was found to result in an increased hydrophobic properties of the compounds. In the presence of the N-butyl radical the mode of the action exerted by the substances changes, viz. from depolarizing they turn into antidepolarizing ones. A substitution of polyalicyclic radicals (cyclohexyl, 1-adamantyl) for methyl groups at the nitrogen atoms in the series of polymethylene-bis-quaternary ammonium compounds proved that in order to changed the mode of action hydrophobic properties of the cyclohexyl radicals appear to be good enough.
Asunto(s)
Animales , Anuros , Dimetilaminas/farmacología , Conformación MolecularRESUMEN
The lengthening of the alkyl radical at the quaternary nitrogen atom (from -C2H5 to -C20H41) in the series of alkyltrimethylammonium compounds was found to lead to a gradually growing hydrophobicity of the compound. A change in the mechanism responsible for the myoparalytic action of the compound is due to a mounting degree of hydrophobicity. With the methyl group in the molecule of tetramethylammonium replaced with polyalicyclic radicals (bornyl, adamantyl) the compound, acting after a non-depolarizing type, possess a greater degree of hyrophobicity than do substances of the depolarizing type.