RESUMEN
AIM: To assess orthogonal ECG system McFee-Parungao in exercise test performed by patients with ischemic heart disease (IHD). MATERIAL AND METHODS: The trial included 103 patients: 41 patients with IHD, 23 patients with IHD combined with arterial hypertension and 39 control patients free of IHD. All the patients performed bicycle exercise with ECG registration in the corrected orthogonal system of leads modified according to McFee-Parungao. In 11 patients ECG was registered in two systems--orthogonal and standard 12-lead. Sensitivity and specificity in IHD were assessed. RESULTS: Parameters of the bicycle exercise test registered by ECG in the corrected orthogonal system indicated that sensitivity and specificity of this system in IHD patients are not inferior to sensitivity and specificity of the standard 12-lead ECG system. CONCLUSION: The system of orthogonal leads McFee-Parungao is recommended for use in the practice of bicycle exercise tests in IHD patients.
Asunto(s)
Electrocardiografía , Prueba de Esfuerzo , Isquemia Miocárdica/diagnóstico , Adulto , Anciano , Electrocardiografía/métodos , Estudios de Evaluación como Asunto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Isquemia Miocárdica/fisiopatologíaRESUMEN
AIM: Assessment of dopaminergic activity by changes in urine excretion of dopamine, arterial hypertension, blood prolactine, 24-h diuresis and natriuresis in response to a single (2.5 mg) and 7-day (daily dose 5 mg) administration of parlodel in patients with essential hypertension (EH) in menopausal and reproductive age having different serum levels of estrogens. MATERIALS AND METHODS: The indices of 52 hypertensive menopausal women and of 18 women at reproductive age of whom 8 had hypothalamic syndrome were followed up. RESULTS: A single dose parlodel (bromocriptine) in the dose 2.5 mg 2 hours after its administration caused a significant fall in arterial pressure, rise in 24-h diuresis in hypertensive menopausal women (p < 0.01). Parlodel given in a daily dose 5 mg for 7 days in menopausal hypertensive women lowered a significant fall in arterial pressure, blood concentrations of aldosteron, prolactin, aroused dopamine and urinary sodium excretion (p < 0.01). Similar were the changes in hypertensive women at reproductive age with hypothalamic syndrome (n = 8). In such women free of hypothalamic impairment the changes did not occur (n = 10). A significant positive correlation was found between serum levels of prolactine and estradiol in all the hypertensive women in menopause. CONCLUSION: Deficiency of dopaminergic activity in menopause is induced by hypoestrogenemia correlating with serum levels of prolactin. This deficiency was identified in hypertensive menopausal women by the results of acute and prolonged tests with dopamine mimetic--parlodel.
Asunto(s)
Dopamina/sangre , Hipertensión/sangre , Menopausia/metabolismo , Adulto , Aldosterona/sangre , Antihipertensivos/uso terapéutico , Biomarcadores/sangre , Biomarcadores/orina , Presión Sanguínea/efectos de los fármacos , Bromocriptina/uso terapéutico , Agonistas de Dopamina/uso terapéutico , Estradiol/sangre , Femenino , Humanos , Hipertensión/tratamiento farmacológico , Hipertensión/orina , Persona de Mediana Edad , Natriuresis/efectos de los fármacos , Pronóstico , Prolactina/sangre , Sodio/orinaRESUMEN
AIM: To assess a hypotensive effect of redergin (dihydroergotoxin)--agonist of dopaminergic receptors--in monotherapy (4.5-6 mg/day) and in combination with enalapril and amlodipin (10 mg/day). MATERIAL AND METHODS: Redergin in monotherapy or combined therapy was given to 106 hypertensive women in pre- or postmenopause and 24 hypertensive women of reproductive age. Antihypertensive effect was assessed by changes in arterial pressure, frequency and severity of hypertensive crises, diuresis, clinical symptoms of menopausal syndrome. RESULTS: A significant fall in arterial pressure, intensive diuresis, less frequent or absent hypertensive crises, relief of menopausal symptoms were observed on day 10-14 of redergin monotherapy of menopausal patients with mild hypertension and in combined treatment of menopausal women with moderate and severe hypertension. CONCLUSION: Antihypertensive and diuretic effect of redergin confirm a pathogenetic role of deficient dopaminergic activity in development of menopausal hypertension.