RESUMEN
Giant cell hepatitis (GCH) has been rarely described in adult HIV patients, and its outcome remain unknown. We report two cases of GCH among 81 HIV patients co-infected with the hepatitis C virus (HCV). Both patients had a sustained virological response, suppression of HCV viral load and HIV viral suppression after highly active antiretroviral therapy. Our findings would suggest that the presence of giant cells does not influence the clinical course of hepatitis.
Asunto(s)
Células Gigantes/patología , Células Gigantes/virología , Infecciones por VIH/patología , Infecciones por VIH/virología , Hepatitis C/patología , Hepatitis C/virología , Adulto , Terapia Antirretroviral Altamente Activa , Antivirales/uso terapéutico , Infecciones por VIH/tratamiento farmacológico , Hepatitis C/tratamiento farmacológico , Histocitoquímica , Humanos , Hígado/química , Hígado/citología , Hígado/virología , Masculino , Persona de Mediana Edad , Carga ViralAsunto(s)
Anticuerpos Monoclonales , Antígenos de Superficie de la Hepatitis B/análisis , Hepatitis/inmunología , Adolescente , Adulto , Anciano , Niño , Femenino , Hepatitis A/inmunología , Hepatitis B/inmunología , Hepatitis C/inmunología , Humanos , Masculino , Persona de Mediana Edad , Radioinmunoensayo , Juego de Reactivos para DiagnósticoRESUMEN
Intrafamilial spread of HBV infection was evaluated in 85 Italian family groups. Secondary infected cases were observed in 43% of these families, of which 73% showed clusters of HBs positive members, with a prevalence among the family members (children-siblings) of the mother/wife index cases, and no strict relation to their "e" system. The presence of the delta agent in the index case was correlated to a higher percentage of secondary HBs-positive cases, but the intrafamilial spread of delta agent was a rare event. A similar higher incidence of HBV markers was observed among the relatives of the index cases positive for auto-antibodies. The evidence presented suggests the importance of genetic factors in the acquisition and clearance of HBV and delta infections.