RESUMEN
In voltage clamp experiments on the frog Ranvier node, the specific protein reagent, N-bromacetamide, significantly decelerates the sodium inactivation kinetics and makes it incomplete. After treatment with N-bromacetamide, both fast and slow inactivation time constants are increased and the proportion of inactivation components is changed favouring the slowly inactivating one in the wide range of membrane potentials. The results are consistent with a single channel population following the 3-state model of inactivation.
Asunto(s)
Acetamidas/farmacología , Neurilema/efectos de los fármacos , Nódulos de Ranvier/efectos de los fármacos , Canales de Sodio/efectos de los fármacos , Animales , Técnicas In Vitro , Potenciales de la Membrana/efectos de los fármacos , Potenciales de la Membrana/fisiología , Neurilema/fisiología , Perfusión/métodos , Rana ridibunda , Nódulos de Ranvier/fisiología , Canales de Sodio/fisiologíaRESUMEN
The process of epithelialization and the antiseptic effect of nucliderm-gel applied locally have been studied on 63 oncologic patients subjected to radiotherapy. In all cases under study, nucliderm-gel promotes skin epithelialization and has a high antiseptic effect as compared with the drugs applied hitherto.