RESUMEN

Peptide antibiotic with cyanolytic activity was isolated from the IGM52 strain of the Brevibacillus laterosporus Gram-positive spore-forming bacteria. By 1H NMR spectroscopy, this antibiotic was identified as loloatin A, a cyclic decapeptide cyclo(-Asn-Asp-Tyr-Val-Orn-Leu-DTyr-Pro-Phe-DPhe-). The spatial structure of loloatin A in solution was determined. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 4; see also http://www.maik.ru.

Asunto(s)

Antibacterianos/aislamiento & purificación , Bacillus/química , Péptidos Cíclicos/aislamiento & purificación , Secuencia de Aminoácidos , Antibacterianos/química , Antibacterianos/farmacología , Cianobacterias/efectos de los fármacos , Espectroscopía de Resonancia Magnética , Modelos Moleculares , Péptidos Cíclicos/química , Péptidos Cíclicos/farmacología , Conformación Proteica