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Bioorg Med Chem Lett
; 19(6): 1753-7, 2009 Mar 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19217288
RESUMEN
A series of benzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, 11f showed the most potent enzyme inhibitory activity (IC(50)=1.1nM) and antitumor activity in human cancer xenografts in mice.