RESUMEN
Forty-seven psychiatric inpatients, including 26 schizophrenics and 21 nonschizophrenics, were measured on four clinical factors (chronicity, premorbid adjustment, reported symptomatology, and diagnosis) and four indices of reaction time (RT) performance (mean RT, RT variance, and redundancy-associated deficit [RAD] at 3- and 7-second preparatory intervals [PIs] ). Each clinical factor was analyzed in turn as a dependent variable in multiple regression analyses. The RT indices comprised the predictor set in each multiple regression. RAD at 7-second PI is related to chronicity for psychiatric patients in general and for schizophrenic patients in particular. Diagnosis and premorbid adjustment are related primarily to mean RT. No evidence was found that RAD is an artifact of high intertrial variance or long RT latencies, but intertrial variance does play a role in moderating the implications of RAD. The different correlations within schizophrenic and nonschizophrenic groups suggest a) that the Elgin Scale has a different meaning when used with schizophrenics than with nonschizophrenics, and b) that it is not useful to treat schizophrenic and nonschizophrenic disorders on the same continuum. The results in general suggest that the vulnerability factor thought to be associated with RAD militates for greater chronicity across different types of patients. The RAD effect within schizophrenics is nevertheless relatively greater than within other patients.
Asunto(s)
Atención , Tiempo de Reacción , Psicología del Esquizofrénico , Adulto , Enfermedad Crónica , Diagnóstico Diferencial , Hospitalización , Humanos , Trastornos Mentales/diagnóstico , Trastornos Mentales/psicología , Inventario de Personalidad , Análisis de Regresión , Esquizofrenia/diagnóstico , Disposición en Psicología , Ajuste SocialRESUMEN
The reaction time crossover (redundancy associated deficity) scores of 28 process schizophrenics, selected for the presence of crossover, were correlated with the crossover scores of 53 of their first-degree relatives (one to five relatives for each patient.). The resulting product-moment correlation coefficient was .27 (p < .05), thus lending support to the notion of a familial factor in reaction time crossover.
Asunto(s)
Tiempo de Reacción , Esquizofrenia/genética , Familia , Humanos , Modelos GenéticosRESUMEN
A study of genetic markers was undertaken in a kindred containing 19 individuals affected with a depressive illness. The pedigree was selected for study because the distribution of affected family members is consistent with transmission of an autosomal gene for susceptibility to psychiatric abnormality. Evidence against linkage of the postulated dominantly transmitted susceptibility gene with 29 segregating marker loci, including HLA, excluded the postulated gene from 6% of the autosomal genome. However, the distribution of HLA haplotypes in affected sibling pairs and within the family as a whole is compatible with the hypothesis that expression of affective disorder in this family depends in part on an HLA-linked susceptibility gene.
Asunto(s)
Trastorno Depresivo/genética , Marcadores Genéticos , Adolescente , Adulto , Consanguinidad , Femenino , Genes Dominantes , Humanos , Masculino , Persona de Mediana Edad , Linaje , FenotipoRESUMEN
Two families in which aberrations involving chromosome no. 2 had been previously used for linkage studies have been re-examined using banding techniques to identify the breakage sites. In one family a (2; 10)(q21;q24) translocation was identified in individuals previously thought to have a pericentric inversion of chromosome no. 2. In the other, a fragile secondary constriction site was localized to 2q13, and it was shown by bromodeoxy uridine incorporation that the origin of the triradial chromosome no. 2 was by isochromatid breakage and non-disjunction rather than by selective endoreduplication. The three marker sites, 2q13, 2q21 and 10q24, have been analysed for their linkage relationships with 15 informative marker loci which have not yet been assigned to chromosomes other than no. 2 or no. 10. No significant evidence for linkage with any of the loci tested was found.
Asunto(s)
Cromosomas Humanos 1-3 , Cromosomas Humanos 6-12 y X , Ligamiento Genético , Bandeo Cromosómico , Femenino , Humanos , Masculino , Linaje , Translocación GenéticaRESUMEN
A family with an autosomal dominant form of congenital cataract, total nuclear cataract, was examined for genetic linkage between the cataract locus and 30 marker loci. Close linkage was excluded for all of the 21 informative loci. There was no significant evidence for linkage of the cataract locus with any of the marker loci.
Asunto(s)
Catarata/genética , Genes Dominantes , Amilasas/genética , Antígenos de Grupos Sanguíneos , Preescolar , Femenino , Genes , Ligamiento Genético , Humanos , Masculino , Linaje , Fosfoglucomutasa/genética , Transcobalaminas/genética , UTP-Hexosa-1-Fosfato Uridililtransferasa/genética , alfa 1-Antitripsina/genéticaRESUMEN
Linkage analysis of Kell:PTC loci demonstration close linkage, theta = 0.045 with a lod score of 10.78. The results, which include the Sutter blood group, support the hypothesis that Sutter is a part of the Kell system.