RESUMEN
The population structure of Fogo Island, Newfoundland is described using geography, religious affiliation, economic factors (such as the presence of a fish-packing plant), and genetic markers. Five different analytic methods, R-matrix analysis, rii VS. mean per locus heterozygosity, predicted kinship (Ï), mean first passage time, and Mantel matrix comparisons, were applied to the Fogo Island genetic and demographic data. The results suggest that geography plays a role on Fogo Island in the distribution of genes, while religion, ethnicity, and economic factors play less significant roles. The communities with fish-packing plants and tourism serve as migratory "sinks" for Fogo islanders seeking employment. Reproductively, the most isolated village on Fogo Island is Tilting, and this is reflected in its genetic uniqueness, initially caused by Irish settlement and subsequently the action of stochastic processes. © 1995 Wiley-Liss, Inc.
RESUMEN
A crude extract of outdated, washed, frozen and thawed, platelet concentrates was prepared and optimally diluted for use in the A.P.T.T. test as a source of platelet phospholipid (P.F. 3). The extract contained, in addition to P.F. 3, active heparin neutralizing activity (P.F. 4), which was able to neutralize plasma heparin up to a concentration of approximately 0.8 units/ml plasma. Although these observations are of a preliminary nature, it is felt that the extract can be used to follow the "intrinsic" coagulability of plasma samples from patients receiving therapeutic heparin. Utilizing the A.P.T.T. test system, the determination of coagulability and the neturalization of heparin result from the use of this extract in a single test.
Asunto(s)
Plaquetas/fisiología , Conservación de la Sangre/métodos , Factor Plaquetario 4/fisiología , Congelación , Heparina/farmacología , Humanos , Tiempo de Tromboplastina Parcial , Agregación Plaquetaria/efectos de los fármacosRESUMEN
Statistical and serological evidence from a large kindred and two unrelated adults indicates that Targett (Tar) is an antigen in the Rh blood group system and that its presence is assocciated with a weak expression of the Rh antigen D. In the numerical notation the Tar antigen is designated Rh40.
Asunto(s)
Sistema del Grupo Sanguíneo Rh-Hr/genética , Femenino , Ligamiento Genético , Marcadores Genéticos , Humanos , Masculino , Linaje , FenotipoAsunto(s)
Hemoglobinopatías , Complicaciones Hematológicas del Embarazo , Adulto , Anemia de Células Falciformes/genética , Femenino , Muerte Fetal , Genes , Asesoramiento Genético , Enfermedad de la Hemoglobina C/genética , Hemoglobinas Anormales , Humanos , Lactante , Mortalidad Infantil , Recién Nacido , Trabajo de Parto , Embarazo , Rasgo Drepanocítico/sangre , Talasemia/genéticaRESUMEN
In two patients with severe painful sickle cell crisis and a deteriorating clinical course, recovery coincided with large-scale exchange transfusions (6 liters). The one patient, with sickle cell beta thalassemia, achieved a 90% exchange, calculated on the sickle cell hemoglobin present before and after transfusion. The other patient, with sickle cell hemoglobin Hb A, S, and (Hb) C disease, also achieved an 80% exchange calculated on the level of HbA.S. AND C in samples before and after transfusion.
Asunto(s)
Anemia de Células Falciformes/terapia , Recambio Total de Sangre , Adulto , Anemia de Células Falciformes/complicaciones , Bicarbonatos/uso terapéutico , Calcio/uso terapéutico , Cloruros/uso terapéutico , Fiebre/diagnóstico , Enfermedad de la Hemoglobina C/terapia , Heterocigoto , Humanos , Masculino , Sodio/uso terapéutico , Taquicardia/diagnóstico , Talasemia/tratamiento farmacológico , Talasemia/terapiaRESUMEN
Eight patients with beta thalassaemia major suffering from leg ulcers, were treated over an 8-week period with 3 g ascorbic acid daily in a controlled double-blind crossover study. The ulcers of all the patients showed a high rate of either complete or partial healing.
Asunto(s)
Ácido Ascórbico/uso terapéutico , Úlcera de la Pierna/tratamiento farmacológico , Talasemia/complicaciones , Administración Oral , Adolescente , Adulto , Ácido Ascórbico/administración & dosificación , Ensayos Clínicos como Asunto , Femenino , Humanos , Úlcera de la Pierna/complicaciones , Masculino , Proyectos Piloto , PlacebosRESUMEN
161 inhabitants of the Seychelle Islands have been examined for blood group, serum protein, and red cell enzyme polymorphisms. The gene frequency data obtained from this survey supports the anthropological view that the present-day Creole-speaking inhabitants of the Seychelle Islands result from a admixture of African and European stock.
Asunto(s)
Antígenos de Grupos Sanguíneos , Proteínas Sanguíneas , Eritrocitos/enzimología , Polimorfismo Genético , Población Negra , Frecuencia de los Genes , Humanos , Fenotipo , Recombinación Genética , Seychelles , Población BlancaRESUMEN
The characterisation of haemoglobin G Norfolk (alpha2 85 Asp leads to Asn 2) is described. This variant has been identified in the heterozygous state in three apparently unrelated English families of which two are resident in England and the other in Canada.
Asunto(s)
Hemoglobinas Anormales/análisis , Aminoácidos/análisis , Asparagina , Ácido Aspártico , Bromuro de Cianógeno , Electroforesis en Papel , Endopeptidasas , Inglaterra , Femenino , Humanos , Masculino , Fragmentos de Péptidos/análisisAsunto(s)
Homosexualidad , 17-Hidroxicorticoesteroides/orina , 17-Cetosteroides/orina , Adulto , Síntomas Afectivos , Antropometría , Estradiol/orina , Estriol/orina , Estrona/orina , Extraversión Psicológica , Femenino , Homosexualidad/fisiopatología , Humanos , Persona de Mediana Edad , Inventario de Personalidad , Pregnanodiol/orina , Psicología , Cromatina Sexual/análisis , Encuestas y Cuestionarios , Testosterona/análogos & derivados , Testosterona/orinaAsunto(s)
Anemia de Células Falciformes/terapia , Anemia de Células Falciformes/complicaciones , Anemia de Células Falciformes/fisiopatología , Anestesia , Anticoagulantes/uso terapéutico , Aspirina/uso terapéutico , Bicarbonatos/uso terapéutico , Sangre , Velocidad del Flujo Sanguíneo , Viscosidad Sanguínea , Temperatura Corporal , Células de la Médula Ósea , Cianatos/uso terapéutico , Femenino , Ácido Fólico/uso terapéutico , Hemoglobina Falciforme/análisis , Hemólisis , Humanos , Concentración de Iones de Hidrógeno , Higiene , Infarto/etiología , Capacidad de Concentración Renal , Úlcera de la Pierna/etiología , Masculino , Mortalidad Materna , Modelos Estructurales , Embarazo , Complicaciones Hematológicas del Embarazo/terapia , Tromboflebitis/etiología , Urea/uso terapéuticoRESUMEN
An automated alkali denaturation technique which measures fetal haemoglobin is described. This method offers greater speed and a lower standard deviation than comparable manual methods.
Asunto(s)
Hemoglobina Fetal/análisis , Anemia de Células Falciformes/diagnóstico , Autoanálisis/métodos , Niño , Enfermedad de la Hemoglobina C/diagnóstico , Hemoglobinopatías/diagnóstico , Humanos , Recién Nacido , Desnaturalización Proteica , Hidróxido de Sodio , Talasemia/diagnósticoRESUMEN
Haemoglobin A(2) in 11 normal and 42 B thalassaemia minor subjects was estimated by simple visual assessment of the electrophoretogram. The results obtained give rise to doubts as to the reliability of this technique when used to estimate haemoglobin A(2) under normal laboratory conditions.