RESUMEN
Two adult sisters are described. One with a full clinical, hematological and cytogenetic picture of Fanconi's anemia died of monocytic leukemia. The other woman has several malformations and clinical signs which are found in Fanconi's anemia, but does not show any hematological disorder or sign of bone marrow insufficiency. Cytogenetic findings in this case are comparable to those typical cases with Fanconi's anemia. This case is therefore considered to represent a "forme fruste" of Fanconi's anemia.
Asunto(s)
Anemia Aplásica/genética , Anemia de Fanconi/genética , Leucemia Mieloide/genética , Anomalías Múltiples/diagnóstico por imagen , Anomalías Múltiples/genética , Adulto , Aberraciones Cromosómicas , Anemia de Fanconi/complicaciones , Femenino , Humanos , Leucemia Mieloide/complicaciones , Linaje , RadiografíaRESUMEN
In 12 patients with acute myocardial infarction the hemodynamic effects of a single intravenous injection of 30 mg of pentazocine were investigated. The administration of pentazocine resulted in no significant hemodynamic changes. In particular, there was no increase in peripheral vascular resistance and no evidence of decreased left ventricular function or respiratory depression. In the occasional patients who demonstrated an elevation of pulmonary arterial pressure, it was probably due to a direct effect of the drug on the pulmonary vasculature.
Asunto(s)
Hemodinámica/efectos de los fármacos , Infarto del Miocardio/tratamiento farmacológico , Pentazocina/farmacología , Anciano , Presión Sanguínea/efectos de los fármacos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pentazocina/uso terapéutico , Sístole/efectos de los fármacos , Resistencia Vascular/efectos de los fármacosRESUMEN
In 16 patients with acute transmural myocardial infarction the effect of 8 mg of intravenous oxyfedrine followed by an infusion of 0.3 mg/kg body weight per hour on haemodynamics of the pulmonary and systemic circulation and dynamic cardiac indices was investigated. Cardiac rate, systemic arterial blood pressure, minute volume, cardiac output, and tension-time index remained unchanged on the whole. On the other hand oxyfedrine produced a persistant significant decrease of the mean and diastolic pulmonary artery pressure, pulmonary capillary pressure, and of the contraction and pressure-increase time. These effects were also demonstrable in patients previously treated with digitalis. No cardiac arrhythmias were observed. The positive inotropic effect of oxyfedrine is suggested as reason for these changes.
Asunto(s)
Hemodinámica/efectos de los fármacos , Infarto del Miocardio/fisiopatología , Oxifedrina/farmacología , Propiofenonas/farmacología , Anciano , Presión Sanguínea/efectos de los fármacos , Gasto Cardíaco/efectos de los fármacos , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Circulación Pulmonar/efectos de los fármacos , Resistencia Vascular/efectos de los fármacosRESUMEN
In 16 patients with acute transmural myocardial infarction the effect of 8 mg of intravenous oxyfedrine followed by an infusion of 0.3 mg/kg body weight per hour on haemodynamics of the pulmonary and systemic circulation and dynamic cardiac indices was investigated. Cardiac rate, systemic arterial blood pressure, minute volume, cardiac output, and tension-time index remained unchanged on the whole. On the other hand oxyfedrine produced a persistant significant decrease of the mean and diastolic pulmonary artery pressure, pulmonary capillary pressure, and of the contraction and pressure-increase time. These effects were also demonstrable in patients previously treated with digitalis. No cardiac arrhythmias were observed. The positive inotropic effect of oxyfedrine is suggested as reason for these changes.
Asunto(s)
Hemodinámica/efectos de los fármacos , Infarto del Miocardio/tratamiento farmacológico , Oxifedrina/farmacología , Propiofenonas/farmacología , Anciano , Presión Sanguínea/efectos de los fármacos , Gasto Cardíaco/efectos de los fármacos , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Contracción Miocárdica/efectos de los fármacos , Oxifedrina/uso terapéutico , Arteria Pulmonar , Estimulación QuímicaAsunto(s)
Cuidados Críticos/métodos , Fenitoína/administración & dosificación , Adulto , Anciano , Arritmias Cardíacas/tratamiento farmacológico , Tolerancia a Medicamentos , Alemania Occidental , Insuficiencia Cardíaca/tratamiento farmacológico , Humanos , Inyecciones Intravenosas , Unidades de Cuidados Intensivos , Persona de Mediana Edad , Fenitoína/uso terapéuticoRESUMEN
The precise position of a cava catheter can be defined by registration of electrocardiogramm by means of this catheter. The rather simple method by the use of a liquid filled catheter is briefly described, according to the improved method by Halter and Urthaler. Those electrocardiographic potentials, characteristic for each part of the right atrium, allow precise positioning of the tip of the catheter. By continuous registration of atrial electrocardiogram the catheter can be placed exactly between vena cava superior and right atrium. Furthermore, the possibility of registering atrial potentials by this simple means provides immediate recognition of atrial arrhythmias in cardian emmergencies.