RESUMEN
@#Objective To explore the effects of valproate on vestibular migraine （VM） symptom improvement and vestibular function. Methods The patients with VM treated in the Dizziness Diagnosis and Treatment Center of The Second Affiliated Hospital of Naval Medical University from September 1，2019 to May 1，2021 were randomly divided into Valproate group and Flunarizine group. The patients were treated with valproate or flunarizine for three months. Before and after the treatment，the frequency of VM as well as the scores of Visual Analogue Scale （VAS） and Dizziness Handicap Inventory （DHI） items were recorded. Vestibular function was compared in the Valproate group before and after treatment. Results The VM frequency，the total scores of VAS and DHI，and the scores of VAS and DHI items in both groups were significantly reduced after the treatment. The changes in VM frequency，VAS score，DHI-F score，DHI-P score，and total DHI score before and after treatment were significantly greater in the Valproate group than in the Flunarizine group. There was no significant difference in the variation of DHI-E score before and after treatment between the two groups. Abnormal eye movement，gaze，and spontaneous nystagmus decreased significantly in the Valproate group after treatment. There were no significant differences in abnormal caloric test，c-VEMP，o-VEMP，saccade test，smooth pursuit test，and direction-changing positional nystagmus. Conclusion Valproate can significantly improve the symptoms of VM and reduce its frequency. Valproate is more efficient than flunarizine.
RESUMEN
OBJECTIVE@#Our goal was to find whether inreversible function damage of saccule was exist and correlated in Meniere's patients with different audition.@*METHOD@#Senenty-nine patients with unilateral Meniere's disease, who visited the Dizziness Diagnosis and Treatment Centre of the Second Military Medical University from January to July in 2015 were included. They were grouped as slightly audition damage group (41 cases), mildly-severely audition damage group(38 cases). Meanwhile 20 normal controls underwent the research. The cervical vestibular evoked myogenic potentials were conducted in symptom free period.@*RESULT@#There was no significant difference of the C-VEMP inducing rate between slightly audition damage group and normal control group. While a statistically difference showed between mildly-severely audition damage group and normal control group or slightly audition damage group. P1, N1 latency had no statistically difference between three groups. The P1-N1 amplitude and asymmetric ratio had no difference between slightly audition damage group and normal control group, but had a statistically difference between mildly-severely audition damage group and slightly audition damage group, normal control group.@*CONCLUSION@#The function of saccule in Meniere's patients decreased with the aggravation of audition damage.