1.
Bioorg Med Chem Lett
; 20(9): 2928-32, 2010 May 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20378348
RESUMEN
PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats.