RESUMEN

A jaw lesion reported in mink exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD-like chemicals is considered a potential indicator of exposure to these chemicals. Many of the effects of TCDD-like chemicals are induced through interaction with the aryl hydrocarbon receptor. The present study indicates that mink dosed with ß-naphthoflavone, which is an aryl hydrocarbon receptor ligand but not a TCDD-like chemical, also develop the lesion. Environ Toxicol Chem 2019;38:460-463. © 2018 SETAC.

Asunto(s)

Proliferación Celular/efectos de los fármacos , Células Epiteliales/efectos de los fármacos , Mandíbula/efectos de los fármacos , Maxilar/efectos de los fármacos , Visón , beta-naftoflavona/toxicidad , Animales , Relación Dosis-Respuesta a Droga , Células Epiteliales/patología , Femenino , Ligandos , Mandíbula/metabolismo , Mandíbula/patología , Maxilar/metabolismo , Maxilar/patología , Receptores de Hidrocarburo de Aril/metabolismo