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Bioorg Med Chem Lett
; 10(19): 2171-4, 2000 Oct 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11012022
RESUMEN
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are novel, potent and selective inhibitors of lck in vitro. Exploration of C-6 position of the pyrrolo[2,3-d]pyrimidine and the terminal phenyl group structure-activity relationship (SAR) is detailed. Compound 1 is orally active in animal models.