1.
J Org Chem
; 69(15): 5120-3, 2004 Jul 23.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15255748
RESUMEN
A general procedure for the synthesis of 4-arylpiperidines via the coupling of 4-(N-BOC-piperidyl)zinc iodide with aryl halides and triflates is presented. The reaction requires cocatalysis with both Cl(2)Pd(dppf) and a copper(I) species. An improved, safer procedure for the activation of zinc dust is also presented.