RESUMEN
An intraindividual comparative study of proximal tibial marrow defects in nine adult Goettinger miniature pigs (GMPs) was undertaken. The left side of the defect was filled with granular beta-tricalcium phosphate (TCP) ceramic ad modum Cerasorb, and the right side was filled with granular alpha-TCP ceramic ad modum Biobase alpha pore. Simultaneously, dental screw implants were inserted in each ceramic and fixed within the orthotopically replanted corticalis lids. Control defects were made in two other animals. The survival period ranged from 4 to 86 weeks (control study, 16 and 20 weeks). The reorganization and degree of bone regeneration, dynamics of ceramic degradation, and remodeling characteristics of the bone regenerate referring to osseo-integration of the dental implants were examined histomorphologically in nondecalcified specimens. The results reveal that both ceramic types were osteoconductive exclusively. Centripetally oriented angiogene bone regeneration occurred at the margins of the circular defects. Ceramic degradation was performed hydrolytically and within cells. Furthermore, it was demonstrated that decomposition of the intratrabecularly integrated ceramic residues underlies a dynamic process of degradation. Within 86 weeks, nearly 80% to 90% of the larger alpha-TCP granules, and nearly 90% to 95% of the beta-TCP granules were degraded. At this time, especially for the alpha-TCP modification, ceramic microparticles were found in the marrow, either unbound or within polynuclear macrophages. The predictable degradation of both ceramic types provides an early functional adaptation of bone regenerates and facilitates a biofunctional, anisotropic orientation of the neotrabeculae without delay. It is concluded that because of the initially pronounced accumulation of macrophages, dental implants should not be inserted simultaneously with ceramic, but after further progress of ceramic degradation (5 to 6 months after TCP implantation).
Asunto(s)
Materiales Biocompatibles/metabolismo , Sustitutos de Huesos/metabolismo , Fosfatos de Calcio/metabolismo , Cerámica/metabolismo , Implantes Experimentales , Implantes Absorbibles , Animales , Regeneración Ósea , Implantes Dentales , Cinética , Tamaño de la Partícula , Porcinos , Porcinos Enanos , TibiaRESUMEN
A new method for internal fixation of the skull in endoscopic facelifting has been developed using a so-called V-tunnel drill system which eliminates the need for pins and screws to anchor the suspended forehead. This system consists of a conventional drill and a V-tunnel guide. The technique involves anchoring the scalp by means of galea/periosteal stitches and sewing it to the bone with PDS sutures after a V-shaped tunnel has been drilled in the external table to a depth of 5 mm. The sutures can be easily positioned and stitched through the V-tunnel without endangering the cerebrum. This versatile V-tunnel drill procedure is very easy and simple and has many foreseeable applications.
Asunto(s)
Endoscopía/métodos , Frente/cirugía , Hueso Frontal/cirugía , Ritidoplastia/métodos , Técnicas de Sutura , Endoscopios , Humanos , Ritidoplastia/instrumentación , Resultado del TratamientoRESUMEN
DO-7 antibody against p-53 antigen was applied for investigation of melanomas of facial skin (25 cases), oral cavity (17 cases), eye (18 cases) and naevi (25 cases). The p-53 index value (% of p-53 positive cells) was correlated with the thickness of the tumour, the presence of metastases and survival time. The difference in p-53 index between naevi and melanomas was statistically significant (p < < 0.01). A significant correlation was found between the p-53 index value and the thickness of the tumour, the presence of metastases and follow-up for patients with skin, oral and ocular melanomas. The possible diagnostic and prognostic significance of p-53 antigen in melanomas and naevi of the head and neck area is discussed.
Asunto(s)
Neoplasias de Cabeza y Cuello/patología , Melanoma/patología , Neoplasias de la Boca/patología , Nevo/patología , Neoplasias Cutáneas/patología , Proteína p53 Supresora de Tumor/análisis , Anticuerpos , Neoplasias del Ojo/mortalidad , Neoplasias del Ojo/patología , Cara , Neoplasias de Cabeza y Cuello/mortalidad , Inmunohistoquímica , Metástasis Linfática , Melanoma/mortalidad , Neoplasias de la Boca/mortalidad , Metástasis de la Neoplasia , Nevo/mortalidad , Valor Predictivo de las Pruebas , Neoplasias Cutáneas/mortalidad , Tasa de Supervivencia , Factores de TiempoRESUMEN
A new monoclonal antibody prepared against a fragment of Ki-67 antigen MIB, from Dianova, was applied for investigation of malignant melanomas of facial skin (25 cases) and the oral cavity (25 cases), which were routinely embedded in paraffin. The values of the Ki-67 index (expressed as a percentage of positive nuclei) were correlated with TNM characteristics of tumors and patient survival. Significant correlation was found between the Ki-67 index and the level of lymph node involvement (N value), the presence of distant metastases and the time of patient survival. A positive relationship between the Ki-67 value and tumor size was also observed although it lacked statistical significance.
Asunto(s)
Anticuerpos Monoclonales , Melanoma/patología , Mucosa Bucal , Neoplasias de la Boca/patología , Proteínas de Neoplasias/análisis , Proteínas Nucleares/análisis , Neoplasias Cutáneas/patología , Adulto , Anciano , Anciano de 80 o más Años , División Celular/inmunología , Neoplasias Faciales/inmunología , Neoplasias Faciales/patología , Femenino , Humanos , Antígeno Ki-67 , Masculino , Melanoma/inmunología , Melanoma/mortalidad , Melanoma/secundario , Persona de Mediana Edad , Neoplasias de la Boca/inmunología , Neoplasias de la Boca/mortalidad , Estadificación de Neoplasias , Estudios Retrospectivos , Neoplasias Cutáneas/inmunología , Neoplasias Cutáneas/mortalidad , Análisis de SupervivenciaRESUMEN
Cleft lip and palate is known to be associated with a number of other skeletal anomalies. The purpose of this study was to investigate the prevalence of possible malformations of the cervical spine and their relationship to velopharyngeal incompetence. The lateral cephalometric radiographs of 30 patients aged between 14 and 27 years of age with cleft lip and palate were compared with these of a control group, who had been involved in cycle accidents. The radiographs were assessed for morphological anomalies of the first and second cervical vertebrate and, in addition, longitudinal and angular measurements performed. Speech was assessed by electromagnetic articulography. A greater number of cervical spine anomalies were found in patients with cleft lip and palate and these were also associated with significantly (P < 0.05) greater osseous-nasopharyngeal depth.
Asunto(s)
Vértebras Cervicales/anomalías , Vértebras Cervicales/diagnóstico por imagen , Labio Leporino/complicaciones , Fisura del Paladar/complicaciones , Insuficiencia Velofaríngea/etiología , Adolescente , Adulto , Cefalometría , Femenino , Humanos , Masculino , Nasofaringe/anomalías , Nasofaringe/diagnóstico por imagen , Radiografía , Insuficiencia Velofaríngea/diagnóstico por imagenRESUMEN
Human radicular cystic tissue of jaws was found to contain between 0.823 pg/mg to 18.026 pg/mg interleukin 1 beta and from 0.34 pg/mg to 0.708 pg/mg interleukin 1 alpha. No IL-1 beta and alpha could be found in specimens from healthy patients. A finding which may be extremely relevant in cystic growth and episodes of alveolar bone resorption around the cystic lesion.
Asunto(s)
Interleucina-1/análisis , Quiste Radicular/química , Anticuerpos Monoclonales , Ensayo de Inmunoadsorción Enzimática/métodos , Humanos , Quiste Radicular/etiologíaRESUMEN
A case of a 19-year-old female with atlanto-axial fusion and dysplasia of odontoid peg in a cleft lip and palate patient is described. Schematic drawings from radiographs were taken to compare six earlier reported cases of anterior atlas arch fusions with epistropheus including dysplasia or aplasia of odontoid peg from literature.
Asunto(s)
Articulación Atlantoaxoidea/anomalías , Labio Leporino/complicaciones , Fisura del Paladar/complicaciones , Apófisis Odontoides/anomalías , Adulto , Articulación Atlantoaxoidea/diagnóstico por imagen , Femenino , Humanos , Apófisis Odontoides/diagnóstico por imagen , RadiografíaRESUMEN
The oral cavity is a rare location for the development of primary malignant melanoma. Two cases of malignant melanoma of the superior alveolar process are described. The necessity of an early recognition and of clarification concerning the differential diagnosis of oral pigmentation as well as the treatment are discussed, together with a review of the literature.