Asunto(s)
2-Aminopurina/análogos & derivados , Glositis/diagnóstico , Estomatitis Herpética/diagnóstico , 2-Aminopurina/administración & dosificación , Administración Oral , Antivirales/administración & dosificación , Diagnóstico Diferencial , Famciclovir , Glositis/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad , Estomatitis Herpética/tratamiento farmacológicoRESUMEN
New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxyl-2-methylpropanoic acid (9aA: AHL-157) showed very superior activities in decreasing triglyceride, cholesterol, and blood sugar compared to bezafibrate in mice and rats.
Asunto(s)
Hipoglucemiantes/síntesis química , Piperidinas/química , Propionatos/síntesis química , Animales , Modelos Animales de Enfermedad , Hipercolesterolemia/tratamiento farmacológico , Hipertrigliceridemia/tratamiento farmacológico , Hipoglucemiantes/química , Hipoglucemiantes/uso terapéutico , Hipolipemiantes/síntesis química , Hipolipemiantes/química , Hipolipemiantes/uso terapéutico , Masculino , Ratones , Ratones Endogámicos ICR , Piperazina , Piperazinas/química , Propionatos/química , Propionatos/uso terapéutico , Ratas , Ratas Sprague-DawleyRESUMEN
Rheumatoid neutrophilic dermatitis (RND) is a rare cutaneous finding in patients with severe rheumatoid arthritis or with high-titer rheumatoid factors. Most commonly, these lesions are erythematous papules or plaques distributed symmetrically on extensor surfaces. On histologic examination a dense dermal neutrophilic infiltrate without vasculitis is apparent. The pathogenesis of RND is unclear, and few treatments are known. With careful clinical and histologic examination, RND may be differentiated from the wide array of other cutaneous findings in rheumatoid arthritis.