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PURPOSE: The aim of the study was to investigate whether incorrectly compensated eddy currents are the source of persistent X-nuclear spectroscopy and imaging artifacts, as well as methods to correct this. METHODS: Pulse-acquire spectra were collected for 1 H and X-nuclei (23 Na or 31 P) using the minimum TR permitted on a 3T clinical MRI system. Data were collected in 3 orientations (axial, sagittal, and coronal) with the spoiler gradient at the end of the TR applied along the slice direction for each. Modifications to system calibration files to tailor eddy current compensation for each X-nucleus were developed and applied, and data were compared with and without these corrections for: slice-selective MRS (for 23 Na and 31 P), 2D spiral trajectories (for 13 C), and 3D cones trajectories (for 23 Na). RESULTS: Line-shape distortions characteristic of eddy currents were demonstrated for X-nuclei, which were not seen for 1 H. The severity of these correlated with the amplitude of the eddy current frequency compensation term applied by the system along the axis of the applied spoiler gradient. A proposed correction to eddy current compensation, taking account of the gyromagnetic ratio, was shown to dramatically reduce these distortions. The same correction was also shown to improve data quality of non-Cartesian imaging (2D spiral and 3D cones trajectories). CONCLUSION: A simple adaptation of the default compensation for eddy currents was shown to eliminate a range of artifacts detected on X-nuclear spectroscopy and imaging.

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LEVEL OF EVIDENCE: 5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2019.

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This study examined fertilization rates, survival and early life-trait differences of pure farm, wild and first generation (F1) hybrid origin embryos after crossing farm and wild Atlantic salmon Salmo salar. Results show that despite a trend towards higher in vitro fertilization success for wild females, differences in fertilization success in river water are not significantly different among crosses. In a hatchery environment, wild females' progeny (pure wild and hybrids with wild maternal parent) hatched 7-11 days earlier than pure farm crosses and hybrids with farm maternal parents. In addition, pure wild progeny had higher total lengths (LT ) at hatch than pure farm crosses and hybrids. Directions in trait differences need to be tested in a river environment, but results clearly show the maternal influence on early stages beyond egg-size differences. Differences in LT were no longer significant at 70 days post hatch (shortly after the onset of exogenous feeding) showing the need to investigate later developmental stages to better assess somatic growth disparities due to genetic differences. Higher mortality rates of the most likely hybrids (farm female × wild male hybrids) at egg and fry stages and their delayed hatch suggest that these F1 hybrids might be less likely to survive the early larval stages than wild stocks.

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PURPOSE: The proposed method is aimed at reducing eddy current (EC) induced distortion in diffusion weighted echo planar imaging, without the need to perform further image coregistration between diffusion weighted and T2 images. These ECs typically have significant high order spatial components that cannot be compensated by preemphasis. THEORY AND METHODS: High order ECs are first calibrated at the system level in a protocol independent fashion. The resulting amplitudes and time constants of high order ECs can then be used to calculate imaging protocol specific corrections. A combined prospective and retrospective approach is proposed to apply correction during data acquisition and image reconstruction. RESULTS: Various phantom, brain, body, and whole body diffusion weighted images with and without the proposed method are acquired. Significantly reduced image distortion and misregistration are consistently seen in images with the proposed method compared with images without. CONCLUSION: The proposed method is a powerful (e.g., effective at 48 cm field of view and 30 cm slice coverage) and flexible (e.g., compatible with other image enhancements and arbitrary scan plane) technique to correct high order ECs induced distortion and misregistration for various diffusion weighted echo planar imaging applications, without the need for further image post processing, protocol dependent prescan, or sacrifice in signal-to-noise ratio.

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Conventional 1D, spatially nonselective fat saturation can generate uncrushed fat signals in areas far outside the imaging slice where crushers are weak because of reduced gradient linearity. These fat signals can corrupt in-slice water signal, and in functional MRI, they can manifest themselves as artifacts such as clouds in image background or localized signal fluctuation over time. In this article, a spectral-spatial radiofrequency pulse is proposed to replace the conventional, spatially nonselective fat saturation pulse. The advantage of the proposed method is that fat protons far outside the image slice would not be excited because of the spatial selectivity, thereby removing the root cause of the fat aliasing artifacts. The proposed method also preserves thin slice capability, pulse duration, and fat suppression performance of the conventional method. Bloch simulation and human volunteer results show that the method is effective in reducing the fat aliasing artifacts seen in functional MRI.

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Atlantic salmon Salmo salar smolts (n = 181) from two rivers were surgically implanted with acoustic transmitters and released to determine migration route, residency time and survival in a 50 km long estuarine fjord located on the south coast of Newfoundland, Canada. Data obtained from automated receivers placed throughout the Bay d'Espoir fjord indicated that migrating smolts used different routes to reach the outer areas of the fjord. The duration of time that smolts spent in the immediate estuary zone also differed between the two localities (7 and 17 days) although the total time smolts were resident in the fjord was similar and extensive (40 days). Many smolts were resident for periods of 4-8 weeks moving back and forth in the outer part of the fjord where maximum water depths range from 300 to 700 m. Survival in the estuary zone was greater for smolts with prolonged residency in estuarine habitat. Overall smolt survival to the fjord exit was moderately high (54-85%), indicating that the initial phase of migration did not coincide with a period of unusually high mortality.

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Nyquist ghost artifacts are a serious issue in echo planar imaging. These artifacts primarily originate from phase difference between even and odd echo images and can be removed or reduced using phase correction methods. The commonly used 1D phase correction can only correct phase difference along readout axis. 2D correction is, therefore, necessary when phase difference presents along both readout and phase encoding axes. However, existing 2D methods have several unaddressed issues that affect their practicality. These issues include uncharacterized noise behavior, image artifact due to unoptimized phase estimation, Gibbs ringing artifact when directly applying to partial k(y) data, and most seriously a new image artifact under tight field-of-view (i.e., field-of-view slightly smaller than object size). All these issues are addressed in this article. Specifically, theoretical analysis of noise amplification and effect of phase estimation error is provided, and tradeoff between noise and ghost is studied. A new 2D phase correction method with improved polynomial fitting, joint homodyne processing and phase correction, compatibility with tight field-of-view is then proposed. Various results show that the proposed method can robustly generate images free of Nyquist ghosts and other image artifacts even in oblique scans or when cross-term eddy current terms are significant.

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PURPOSE: To address phase and amplitude errors for multi-point water-fat separation with "bipolar" acquisitions, which efficiently collect all echoes with alternating read-out gradient polarities in one repetition. MATERIALS AND METHODS: With the bipolar acquisitions, eddy currents and other system nonidealities can induce inconsistent phase errors between echoes, disrupting water-fat separation. Previous studies have addressed phase correction in the read-out direction. However, the bipolar acquisitions may be subject to spatially high order phase errors as well as an amplitude modulation in the read-out direction. A method to correct for the 2D phase and amplitude errors is introduced. Low resolution reference data with reversed gradient polarities are collected. From the pair of low-resolution data collected with opposite gradient polarities, the two-dimensional phase errors are estimated and corrected. The pair of data are then combined for water-fat separation. RESULTS: We demonstrate that the proposed method can effectively remove the high order errors with phantom and in vivo experiments, including obliquely oriented scans. CONCLUSION: For bipolar multi-echo acquisitions, uniform water-fat separation can be achieved by removing high order phase errors with the proposed method.

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Metallic implants used in bone and joint arthroplasty induce severe spatial perturbations to the B0 magnetic field used for high-field clinical magnetic resonance. These perturbations distort slice-selection and frequency encoding processes applied in conventional two-dimensional MRI techniques and hinder the diagnosis of complications from arthroplasty. Here, a method is presented whereby multiple three-dimensional fast-spin-echo images are collected using discrete offsets in RF transmission and reception frequency. It is demonstrated that this multi acquisition variable-resonance image combination technique can be used to generate a composite image that is devoid of slice-plane distortion and possesses greatly reduced distortions in the readout direction, even in the immediate vicinity of metallic implants.

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Partial k-space sampling is frequently used in single-shot diffusion-weighted echo-planar imaging (DW-EPI) to reduce the TE and thereby improve the SNR. However, it increases the sensitivity of the technique to bulk rotational motion, which introduces a phase gradient across the tissue that shifts the echo in k-space. If the echo is displaced into the high spatial frequencies, conventional homodyne reconstruction fails, causing intensity oscillations across the image. Zero-padding, on the other hand, compromises the image resolution and may cause truncation artifacts. We present an adaptive version of the homodyne algorithm that detects the location of the echo in k-space and adjusts the center and width of the homodyne filters accordingly. The adaptive algorithm produces artifact-free images when the echo is shifted into the high positive k-space range, and reduces to the standard homodyne algorithm in the absence of bulk motion.

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In MRI of human brain, the respiratory cycle can induce B0-field fluctuations through motion of the chest and fluctuations in local oxygen concentration. The associated NMR frequency changes can affect the MRI data in various ways and lead to temporal signal fluctuations, and image artifacts such as ghosting and blurring. Since the size of the effect scales with magnetic field strength, artifacts become particularly problematic at fields above 3.0T. Furthermore, the spatial dependence of the B0-field fluctuations complicates their correction. In this work, a new method is presented that allows compensation of field fluctuations by modulating the B0 shims in real time. In this method, a reference scan is acquired to measure the spatial distribution of the B0 effect related to chest motion. During the actual scan, this information is then used, together with chest motion data, to apply compensating B0 shims in real time. The method can be combined with any type of scan without modifications to the pulse sequence. Real-time B0 shimming is demonstrated to substantially improve the phase stability of EPI data and the image quality of multishot gradient-echo (GRE) MRI at 7T.

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Acoustic noise has always been associated with MRI and fMRI. During clinical use, the noise provides a source of irritation to both patients and operators. Within research imaging, the noise creates errors in fMRI, especially for fMRI involving auditory stimulus. Prior studies have attempted to reduce the noise received by subjects using active noise cancellation and statistical prediction algorithms to determine what antinoise to emit, resulting in sound pressure level (SPL) attenuation of 4 to 30 dB. This paper proposes that the noise generated during imaging does not vary on a session by session basis. This should allow a recording of the noise to be used in active noise cancellation instead of predictive algorithms.

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Clinical application of high-temperature thermal therapy as a treatment for solid tumours requires an accurate and close to real-time method for assessing tissue damage. Imaging methods that detect structural changes during heating may underestimate the extent of thermal damage. This is due to the occurrence of delayed damage manifested at tissue locations exposed to temperatures lower than those required to cause immediate structural changes. An alternative approach is to measure temperature and then calculate the expected damage based on the temperature history at each tissue location. Magnetic resonance (MR) imaging methods now allow temperature maps of the target and surrounding tissues to be generated in almost real-time. The aim of this work was to evaluate whether thermal damage zones calculated on the basis of MR thermometry maps measured during heating correspond to actual tissue damage as measured after treatment by histological methods and MR imaging. Four male rabbits were treated with high-temperature thermal therapy delivered in the brain by a single microwave antenna operating at 915 MHz. MR scanning was performed before, during and after treatment in a 1.5 T whole-body scanner. Temperature maps were produced using the proton resonance frequency (PRF) shift method of MR thermometry. In addition, conventional T1-weighted and T2-weighted spin-echo images were acquired after treatment. Thermal damage zones corresponding to cell death, microvascular blood flow stasis and protein coagulation were calculated using an Arrhenius analysis of the MR temperature/time course data. The calculated zones were compared with the lesions seen on histopathological examination of the brains which were removed within 6-8 h of treatment. The results showed that calculated damage zones based on MR thermometry agreed well with areas of damage as assessed using histology after heating was completed. The data suggest that real-time calculations of final expected thermal damage based on an Arrhenius analysis of MR temperature data may provide a useful method of real-time monitoring of thermal therapy when combined with conventional T2-weighted images taken after treatment.

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Percutaneous interstitial microwave thermoablation of locally recurrent prostate carcinoma was continually guided with magnetic resonance (MR) imaging. Phase images and data were obtained with a rapid gradient-echo technique and were used to derive tissue temperature change on the basis of proton-resonance shift. Thermally devitalized regions correlated well with the phase image findings. MR imaging-derived temperatures were linearly related to the fluoroptic tissue temperatures. MR imaging can be used to guide thermoablation.

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The proton-resonance frequency (PRF) shift method of thermometry has become a promising tool for magnetic resonance image-guided thermal therapies. Although the PRF thermal coefficient has recently been shown to be independent of tissue type when measured ex vivo, significant discrepancy remains on its value for tissues measured in vivo under a variety of experimental conditions. The authors identify a potential source of variation in the PRF thermal coefficient that arises from temperature-induced changes in the volume magnetic susceptibility of tissue and is dependent on the orientation and geometry of the heat-delivery device and its associated heat pattern. This study demonstrates that spatial variations in the apparent PRF thermal coefficient could lead to errors of up to +/-30% in the magnetic resonance estimated temperature change if this effect is ignored.

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The requirements for access and imaging performance compete in the design of open-concept MR magnets and gradient coils. We conducted a theoretical and experimental investigation of gradient coil design using both solid and laminated pole piece construction to determine whether adequate eddy current control can be obtained without shielded gradient coils while maintaining good patient access and high gradient performance. Eddy currents, gradient characteristics, gradient efficiency, and magnet openness are compared and contrasted for various construction options based on a compact, .27 T iron yoke magnet. The resulting pole pieces and gradient coils have high efficiency for an interventional open-configuration magnet while taking up minimal space between the poles for improved patient access.

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The temperature sensitivity of the proton-resonance frequency (PRF) has proven valuable for the monitoring of MR image-guided thermal coagulation therapy. However, there is significant inconsistency in reported values of the PRF-thermal coefficient, as measured from experiments encompassing a range of in vivo and ex vivo tissue types and experimental conditions. A method of calibrating the temperature dependence of the PRF is described and results are presented that indicate a tissue-type independence. To this end, other possible mechanisms for variations in the PRF-thermal coefficient are suggested, including physiological perturbations and volume magnetic susceptibility effects from geometry and orientation.

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An MR-based method for tracking subject motion is presented. The technique identifies subject motion from the three-dimensional positions of three small samples attached to the subject in a fixed, triangular configuration. The updated positions of these samples relative to their initial positions determine a rigid body transformation. Applied to the MRI scan prescription via adaptive feedback controls, this transformation yields an updated MRI scan plane that tracks the prescribed imaging section as the subject moves. The scan-plane tracking procedure is demonstrated experimentally for two-dimensional imaging of a standard imaging phantom and the head of a human subject. Sets of images were acquired sequentially, with motion (translations and/or rotations) introduced between image frames. The scan-plane tracking system provides well registered image slices of the same section, adaptively compensating for the subject motion.

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Chemical shift artifacts and other off-resonance spatial shifts in 2DFT MRI arise from the linear time dependence in the k-space data in the readout direction. Introduction of a view-dependent time shift of the readout window adds a time dependence to the phase-encoding direction and results in a virtual frequency-encoding direction that is a linear combination of the phase-encode and readout axes. By this method, the readout and phase-encode directions can be made identical in their sensitivity to off-resonance effects and can be arbitrarily swapped with no change in chemical shift or inhomogeneity effects, improving previously reported methods that swap these axes for signal averaging or reduction of motion artifacts.

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The use of MRI to guide and monitor interventional procedures requires the merging of surgical and MRI environments. The ideal magnet shape for homogeneity and efficiency is spherical, but this design provides no access. Opening the sphere to provide both patient and surgeon access suggests cylindrical or biplanar magnets. Cylindrical magnets have poor surgical access but provide good imaging capabilities, which can be used in conjunction with a neighboring but distinct surgical environment. Biplanar magnets provide more and better approaches to the patient, but generally with lower field strength. Vertical biplanar systems allows surgical approaches from above but reduce the access of support staff to the patient. A hybrid magnet design, which combines the benefits of both cylindrical and biplanar magnets, can provide increased access with simultaneous approach from two sides of the patient. Application-specific magnets can target a smaller region, leading to compact magnet designs that greatly expand access for both surgical intervention as well as patient support. As the field of interventional MRI matures, the suitability of each design to specific applications will be better understood, leading to more integrated system designs tailored to the needs of image-guided therapy.

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