RESUMEN
BACKGROUND: Fracture of the denture base is a common problem associated with dental prostheses. Fractured denture base surfaces treated with chemical agents and mechanical features have the potential for improved bond strength. AIM: The aim of this study was to evaluate the effect of surface treatment on the shear bond strength of heat-cured denture base with different repair acrylic resins. MATERIALS AND METHODS: A total of 100 circular specimens (2-cm diameter × 3.3-mm thickness) were fabricated from heat-cured denture resins (DPI) according to the manufacturer's instructions. The heat-cured denture base acrylic resin specimens were divided into two groups: In group 1, auto-polymerizing acrylic resin (DPI) was used as a repair resin, and in group 2, light-cured acrylic resin (VLC) was used as the repair resin. Further, the heat-cured denture base acrylic resin specimens were subdivided into five subgroups. The shear bond strength (in megapascal) was measured in a universal testing machine at a crosshead speed of 1 mm/min. The results were subjected for statistical analysis. RESULT: Comparison of mean and standard deviation of shear bond strength between DPI and VLC group using one-way analysis of variance showed that the mean shear bond strength of DPI group is higher than that of VLC group. CONCLUSION: From the study, heat-cured denture base specimens repaired with auto-polymerizing repair resin showed higher mean shear bond strength than the visible light cure resin material.
RESUMEN
OBJECTIVES: To analyse the capacity of routine assessment of patient index data 3 (RAPID3), an index of only the three patient-reported outcome (PRO) measures in the RA Core Data Set-physical function, pain and global status-to distinguish abatacept from control treatments in two clinical trials, and to compare RAPID3 results with the disease activity score 28 (DAS28) and RAPID-based indices that add a tender or swollen joint count and/or physician/assessor global estimate of status. METHODS: Clinical trial data from AIM (Abatacept in Inadequate response to Methotrexate) and ATTAIN [Abatacept Trial in Treatment of Anti-tumor necrosis factor (anti-TNF) INadequate responders] were reanalysed. Mean values were computed at baseline, endpoint and for change between baseline and endpoint for RAPID3, DAS28 and additional RAPID indices to study whether they had greater capacity to distinguish abatacept from control therapy. RAPID4TJC adds to RAPID3 a tender joint count; RAPID4SJC, a swollen joint count; RAPID4MD, a physician/assessor global estimate; and RAPID5 adds both a tender joint count and physician/assessor global estimate. RAPID2 includes only physician/assessor and patient global estimates. RESULTS: All indices indicated significant differences of 19-28% between abatacept and control groups. Results were similar for RAPID3 of only patient measures, compared to DAS28 and other RAPID-based indices. CONCLUSION: A RAPID3 'patient-only' index, without a joint count or any measure from a health professional or laboratory, distinguishes active from control treatments in two abatacept clinical trials, at levels similar to DAS28 and to other RAPID-based indices that add physician-reported measures.
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Artritis Reumatoide/tratamiento farmacológico , Indicadores de Salud , Inmunoconjugados/uso terapéutico , Metotrexato/uso terapéutico , Participación del Paciente , Rango del Movimiento Articular/fisiología , Abatacept , Actividades Cotidianas , Antirreumáticos/uso terapéutico , Artritis Reumatoide/diagnóstico , Estudios de Evaluación como Asunto , Femenino , Humanos , Inflamación/tratamiento farmacológico , Inflamación/fisiopatología , Masculino , Registros Médicos , Estudios Multicéntricos como Asunto , Dimensión del Dolor/efectos de los fármacos , Satisfacción del Paciente , Médicos , Probabilidad , Ensayos Clínicos Controlados Aleatorios como Asunto , Rango del Movimiento Articular/efectos de los fármacos , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad , Estadísticas no Paramétricas , Resultado del TratamientoRESUMEN
OBJECTIVES: To test the theory of planned behavior as a model for predicting and understanding behavioral intentions for fighting among inner-city adolescents and to determine whether its predictive power differs as a function of ethnicity (African American versus Latino). METHODS: Participants were 956 (511 females, 445 males) African American (n = 702) and Latino (n = 254) adolescents (mean age = 12.72 years; SD = 1.12) recruited from sixth, seventh, and eighth grade classes in public middle schools serving two inner-city communities in New Jersey who completed self-administered, confidential questionnaires. RESULTS: Consistent with the theory of planned behavior, hierarchical multiple regression analyses revealed that attitudes, subjective norms, and perceived behavioral control predicted intentions for fighting. Although the theory of planned behavior accounted for substantial variance in intentions to fight in both ethnic groups, it accounted for greater variance among Latinos than among African Americans. The strength of the relations of subjective norms and perceived behavioral control to intentions was similar in the two groups. but the relation of attitudes to intentions to fight was significantly stronger among Latinos. CONCLUSIONS: The findings strongly suggest that the theory of planned behavior provides a potentially useful conceptual framework for guiding the creation of interventions for African American and Latino adolescents that are designed to reduce violent behavior and the tragedies that such behavior leaves in its wake.
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Conducta , Negro o Afroamericano , Hispánicos o Latinos , Violencia , Adolescente , Actitud , Análisis Factorial , Humanos , Modelos Psicológicos , New Jersey , Población UrbanaRESUMEN
This paper describes the efforts of the faculty of the Family Institute of New Jersey in recent years to develop a collaborative family training program that takes into account issues of gender, race, culture, class, and sexual orientation. We have come to realize how strongly traditional approaches have been skewed in the direction of the dominant culture--white, male, heterosexist, and prioritizing the needs and experience of the middle and upper classes. We have attempted to modify our teaching, supervision, reading lists, and overall training approach to challenge trainees and ourselves to move toward broader, strength-based, and equity-based multicultural perspectives in our training. We describe our vision, how we incorporate it into our program structure, and a few of our training initiatives.
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Educación , Terapia Familiar/educación , Familia , Justicia Social , Adulto , Diversidad Cultural , Cultura , Curriculum , Femenino , Humanos , Aprendizaje , Masculino , PrejuicioAsunto(s)
Evolución Biológica , Sexo , Animales , Femenino , Impresión Genómica , Humanos , Masculino , Recombinación Genética , Conducta Sexual , Conducta Sexual AnimalRESUMEN
Sickle red blood cell (RBC) adhesion to the endothelium and to exposed, underlying subendothelial proteins is believed to contribute to vascular occlusion in sickle cell disease. Laminin, a major component of the subendothelium, supports significant adhesion of sickle, but not normal RBCs. The purpose of this study was to define the adhesive region for sickle RBCs within a human laminin preparation using a flow adhesion assay designed to mimic physiologic flow through postcapillary venules. Because sickle RBCs did not adhere to the common laminin contaminants entactin or collagen type IV, neither of these proteins are likely to contribute to the observed adhesion to laminin. Known adhesive regions of laminin neither supported nor inhibited sickle RBC adhesion to laminin, suggesting a mechanism of adhesion previously uncharacterized in other laminin adhesion studies. Moreover, sickle RBCs did not adhere to mouse EHS laminin or to human laminin-2 (merosin), eliminating the alpha1, alpha2, beta1, and gamma1 chains as mediators of sickle cell adhesion. The monoclonal antibody 4C7, which binds at or near the G-domain of the laminin alpha5 chain, significantly inhibited sickle RBC adhesion. These results suggest that an adhesive region for sickle RBCs is contained within the laminin alpha5 chain.
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Anemia de Células Falciformes/patología , Eritrocitos Anormales/patología , Laminina/metabolismo , Anemia de Células Falciformes/complicaciones , Animales , Adhesión Celular , Endotelio Vascular/citología , Endotelio Vascular/metabolismo , Proteínas de la Matriz Extracelular/metabolismo , Humanos , Laminina/química , Ratones , Microcirculación , Estructura Terciaria de Proteína , Relación Estructura-ActividadRESUMEN
The moisture level in a hygroscopic drug substance was successfully determined by near infrared spectroscopy using coulometric Karl Fischer titration as the reference method. The importance of sample handling and proper application of the reference technique are stressed for this difficult sample type. Samples were prepared with moisture levels from 0.5 to 11.4% (w/w) and reflectance spectra were collected over the spectral range 1100-2500 nm. Calibration models were built using partial least squares (PLS) regression analysis. Optimum models were found by choosing proper spectral ranges and number of PLS factors. The best calibration models were built using first derivative spectra, a spectral range of 1850-1936 nm and 5 PLS factors. The corresponding standard error of prediction was 0.11% (w/w) water.
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Preparaciones Farmacéuticas/análisis , Agua/análisis , Calibración , Análisis de Regresión , Espectrofotometría Infrarroja/métodos , Volumetría , HumectabilidadAsunto(s)
Células Quimiorreceptoras/metabolismo , Odorantes , Feromonas/metabolismo , Receptores Odorantes/genética , Órgano Vomeronasal/fisiología , Animales , Células Quimiorreceptoras/química , Proteínas de Unión al GTP/metabolismo , Genes , Receptores Odorantes/química , Receptores Odorantes/metabolismoRESUMEN
Benchmarking is a process of comparing an organization's performance to that of a selected standard. Because the standard is one selected from other organizations for their "best" performance, benchmarking establishes a vision or goal for restructuring. This author, who is experienced in helping organizations restructure using the benchmarking process describes the steps and how to use it to guide an organization to successful restructuring.
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Reestructuración Hospitalaria/normas , Garantía de la Calidad de Atención de Salud , Administración Hospitalaria , Humanos , Enfermeras AdministradorasRESUMEN
Clinical documentation can take up to 25 percent of a nurse's time in an acute care setting, not to mention the time spent by other clinicians and ancillary caregivers on documentation. Institutions can reduce documentation time by systematically determining what information is crucial to the provision of patient care across all disciplines and then using a redesign process that mirrors work redesign. By following a structured process that challenges the philosophy and function of the documentation system, a hospital's multidisciplinary staff members can use their expertise to design alternatives that achieve documentation's original intent-to document diagnoses and treatment accurately-in a more efficient and useful way.
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Enfermeras Clínicas , Relaciones Enfermero-Paciente , Registros de Enfermería/normas , Administración del Tiempo , Simplificación del Trabajo , Carga de Trabajo , Control de Costos , Ahorro de Costo , Eficiencia Organizacional , Control de Formularios y Registros , Humanos , Registros Médicos Orientados a Problemas , Evaluación de Procesos y Resultados en Atención de Salud , Grupo de Atención al PacienteRESUMEN
Redefining roles of patient caregivers as an element of work restructuring is essential to maintain and/or enhance an organization's efficiency in this competitive health care environment. This process works best when all levels and disciplines within the organization are involved and when meshed with senior management's leadership and vision.
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Cuidadores , Reestructuración Hospitalaria , Perfil Laboral , Personal de Enfermería , Humanos , Modelos de EnfermeríaAsunto(s)
Desarrollo Embrionario , Desarrollo Embrionario y Fetal , Crecimiento , Animales , Evolución Biológica , Humanos , MorfogénesisRESUMEN
We introduced a normal chromosome 11 into GM979 murine erythroleukemia cells by fusing them with Epstein-Barr virus-transformed lymphocytes from a normal individual. In contrast to previous data obtained with other murine erythroleukemia cells, we detected activation of human chromosomal gamma-globin genes in GM979 cells. GM979, unlike previously used murine erythroleukemia cell lines, expresses murine embryonic globin in addition to adult globin. While all the hybrids expressed gamma- and beta-globin, they displayed a wide range of gamma-globin expression in relation to that of beta-globin. No correlation, however, was found in quantitative expression between murine embryonic globin and human gamma-globin in these hybrids, suggesting that the two globins are regulated independently, at least in this cell line. These data indicate that gamma-globin genes from normal, nonerythroid chromosomes are not irreversibly silenced, and they can be activated by a positive trans factor(s) present in GM979 cells.