RESUMEN
The mechanism of amiodarone-induced pulmonary toxicity is unknown. Two cases of amiodarone pulmonary toxicity are presented in which abnormal inclusion bodies containing whorls of membrane were seen on electron microscopy of extrapulmonary tissues. These cytoplasmic lysosomal inclusion bodies were observed in lymphocytes, plasma cells, granulocytes, tissue macrophages, and hepatocytes. These widespread histopathologic changes in extrapulmonary tissues and in a variety of cell types are similar to more extensively investigated findings in animal models that are thought to represent a drug-induced lysosomal storage disease, phospholipidosis.
Asunto(s)
Amiodarona/efectos adversos , Benzofuranos/efectos adversos , Leucocitos/ultraestructura , Hígado/ultraestructura , Enfermedades Pulmonares/inducido químicamente , Pulmón/ultraestructura , Ganglios Linfáticos/ultraestructura , Biopsia con Aguja , Estudios de Seguimiento , Humanos , Cuerpos de Inclusión/ultraestructura , Leucocitos/efectos de los fármacos , Hígado/efectos de los fármacos , Pulmón/efectos de los fármacos , Enfermedades Pulmonares/diagnóstico por imagen , Enfermedades Pulmonares/patología , Ganglios Linfáticos/efectos de los fármacos , Lisosomas/ultraestructura , Masculino , Microscopía Electrónica , Persona de Mediana Edad , Radiografía , Taquicardia/tratamiento farmacológicoRESUMEN
Nuclear magnetic resonance (NMR) images of the thorax were obtained in ten normal volunteers, nine patients with advanced bronchogenic carcinoma, and three patients with benign thoracic abnormalities. In normal volunteers, mediastinal and hilar structures were seen with equal frequency on NMR images and computed tomographic scans. The hila were especially well displayed on spin-echo images. Spin-echo images showed mediastinal invasion by tumor, vascular and bronchial compression and invasion, and hilar and mediastinal adenopathy. Tumor and benign abnormalities could be separated from mediastinal and hilar fat because of their longer T1 times. Lung masses and nodules as small as 1.5 cm could be seen on the spin-echo images. NMR imaging shows promise for assessment of benign and malignant mediastinal, hilar, and lung abnormalities.
Asunto(s)
Espectroscopía de Resonancia Magnética , Tórax/diagnóstico por imagen , Adulto , Anciano , Carcinoma Broncogénico/diagnóstico por imagen , Humanos , Neoplasias Pulmonares/diagnóstico por imagen , Persona de Mediana Edad , Radiografía Torácica , Cintigrafía , Valores de Referencia , Enfermedades Torácicas/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
Computed tomography (CT) demonstrated nodular thickening with calcification in the anterior and lateral tracheal walls of a patient with tracheobronchopathia osteochondroplastica. The CT findings in this rare disease are pathognomonic.
Asunto(s)
Enfermedades Bronquiales/diagnóstico por imagen , Calcinosis/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Enfermedades de la Tráquea/diagnóstico por imagen , Anciano , Broncografía , Humanos , Masculino , Tráquea/diagnóstico por imagenRESUMEN
A 44-year-old woman with a superior caval syndrome was found to have an isolated plasmacytoma of the right atrium causing partial obstruction of the superior and inferior vena cavae. The tumor was excised locally, and after operation, irradiation was given. There has been no local recurrence or systemic disease demonstrated after 30 months. This is the first reported surgical excision of an intracardiac plasmacytoma.