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Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.

Kennedy, L J; Quarmby, S; Happ, G M; Barnes, A; Ramsey, I K; Dixon, R M; Catchpole, B; Rusbridge, C; Graham, P A; Hillbertz, N S; Roethel, C; Dodds, W J; Carmichael, N G; Ollier, W E R.

Tissue Antigens ; 68(1): 82-6, 2006 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-16774545

RESUMEN

Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.

Asunto(s)

Alelos , Enfermedades de los Perros/genética , Enfermedades de los Perros/inmunología , Genes MHC Clase II , Antígenos de Histocompatibilidad Clase II/genética , Hipotiroidismo/veterinaria , Animales , Perros , Antígenos de Histocompatibilidad Clase II/inmunología , Hipotiroidismo/genética , Hipotiroidismo/inmunología

RESUMEN

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