RESUMEN

The association between a prothrombin mutation and the risk of thrombosis was analyzed in 214 patients with polycythemia vera or essential thrombocythemia. The rate for venous thrombotic events was 14.7/100 patient-years in patients with the prothrombin mutation compared to 0.8 in patients without the mutation (rate ratio 17.5).

Asunto(s)

Mutación , Protrombina/genética , Trombosis/genética , Anciano , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Policitemia Vera/complicaciones , Policitemia Vera/epidemiología , Policitemia Vera/genética , Trombocitemia Esencial/complicaciones , Trombocitemia Esencial/epidemiología , Trombocitemia Esencial/genética , Trombosis/etiología