RESUMEN

Febrile seizures (FSs) are the most common convulsive event in children. Inflammatory elements and genetics have major roles in their pathogenesis. As of the importance of interleukin-6 (IL-6) in FS, this study was performed to assess IL6 single nucleotide polymorphisms (SNPs) in a group of patients with FS. IL6 gene (-174 and +565) SNPs were studied on genomic DNAs of 90 children with FS, using PCR-SSP method. The results were compared to 139 healthy individuals. The presence of the G allele or the GG genotype at +565 position reduced risk of FS, while the A allele at +565 position of the promoter regions was a constituted risk factor for developing FS. This study could support the idea that IL6 SNPs play a role in the pathogenesis of FS.

Asunto(s)

Interleucina-6/genética , Polimorfismo de Nucleótido Simple/genética , Convulsiones Febriles/genética , Alelos , Estudios de Casos y Controles , Preescolar , Femenino , Predisposición Genética a la Enfermedad/genética , Genotipo , Humanos , Lactante , Masculino , Regiones Promotoras Genéticas/genética