1.
Transl Neurodegener
; 13(1): 42, 2024 Aug 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-39160618
RESUMEN
Alzheimer's disease (AD) is a progressive neurological disorder that primarily impacts cognitive function. Currently there are no disease-modifying treatments to stop or slow its progression. Recent studies have found that several peripheral and systemic abnormalities are associated with AD, and our understanding of how these alterations contribute to AD is becoming more apparent. In this review, we focuse on amyloidbeta (Aß), a major hallmark of AD, summarizing recent findings on the source of brain-derived Aß and discussing where and how the brain-derived Aß is cleared in vivo. Based on these findings, we propose future strategies for AD prevention and treatment, from a novel perspective on Aß metabolism.