RESUMEN
A new labdane diterpene, along with 10 known sterols and flavonoids, was isolated from the hydroalcoholic extract of the leaves of Saraca indica. The chemical structure of the new compound was identified as 6,9-epoxy marrubiinic acid on the basis of spectroscopic analyses including two-dimensional NMR. The antimicrobial potential of the new compound was evaluated against Gram-positive and Gram-negative bacteria as well as fungi. It showed a significant antifungal activity against Geotrichum candidum with MIC 0.48 µg/mL. It also showed potential cytotoxicity against human cancer cell lines with IC50 ranging from 1.07 to 1.29 µg/well.
RESUMEN
Teucrol, a decarboxy rosmarinic acid and its triglycoside, teucroside, 9'-decarboxyrosmarinic acid-4'-O-alpha-rhamnosyl-(1'''-->6''')-O-beta-galactosyl-(1'''-->4'')-O-alpha-rhamnoside, are two new natural phenolics which have been isolated and identified from the aqueous alcohol extract of the whole plant of Teucrium pilosum (Decne) Asch. & Schweinf. (Lamiaceae). Structures were determined by conventional methods of analysis and confirmed by MS and NMR spectral analysis, including 2D-homonuclear COSY experiment.