Asunto(s)
Donantes de Sangre , ADN Viral/sangre , Países en Desarrollo , Tamizaje Masivo/métodos , ARN Viral/sangre , Tiras Reactivas , Infecciones por VIH/diagnóstico , Infecciones por VIH/virología , VIH-1/genética , Hepacivirus/genética , Hepatitis B/diagnóstico , Hepatitis B/virología , Virus de la Hepatitis B/genética , Hepatitis C/diagnóstico , Hepatitis C/virología , Humanos , Técnicas de Amplificación de Ácido Nucleico/instrumentación , Técnicas de Amplificación de Ácido Nucleico/métodos , Reacción a la TransfusiónRESUMEN
We evaluated 100 consecutive cases of lone aortic insufficiency (AI) for the prevalence of seronegative spondyloarthropathies. Four patients were found to have ankylosing spondylitis and three had Reiter's syndrome. Six of these seven patients had cardiac conduction abnormalities, four of which required permanent pacemaker insertion. All seven were found to have the HLA-B27 antigen, whereas of 89 patients tested with no evidence of spondylitis only five had the antigen. The seronegative spondyloarthropathies apparently are associated frequently with lone AI. The morbidity and mortality of these patients increases when they develop cardiovascular abnormalities including AI and heart block, which may dominate the clinical picture. The HLA-B27 antigen is not specifically associated with lone AI in the absence of spondylitis.
Asunto(s)
Insuficiencia de la Válvula Aórtica/complicaciones , Artritis Reactiva/complicaciones , Antígenos HLA/análisis , Espondilitis Anquilosante/complicaciones , Adulto , Anciano , Insuficiencia de la Válvula Aórtica/inmunología , Insuficiencia de la Válvula Aórtica/patología , Artritis Reactiva/inmunología , Estudios Transversales , Femenino , Antígeno HLA-B27 , Humanos , Masculino , Persona de Mediana Edad , Espondilitis Anquilosante/inmunologíaRESUMEN
Electrophysiologic investigation of a diffuse and bizarre conduction abnormality in a patient with cardiomyopathy revealed profound slowing of the impulse in the right ventricular outflow region. The resultant 220 msec QRS duration is the longest reported in right bundle branch block.