RESUMEN
A novel, efficient and enantioselective Heck-Matsuda desymmetrization of non-activated cyclopentene-fused spiro-pyrrolidinones was developed. The reaction provided the Heck products in good to excellent yields and selectivities and tolerated a variety of functional groups in arenediazonium tetrafluoroborates (12 examples) with respect to its electronics and substitution patterns. This methodology was successfully applied in the concise enantioselective total synthesis of VPC01091 (2b), a drug candidate for the treatment of multiple sclerosis.
Asunto(s)
Ciclopentanos/química , Pirrolidinonas/química , Receptores de Lisoesfingolípidos/metabolismo , Compuestos de Espiro/química , Técnicas de Química Sintética , Ciclopentanos/síntesis química , Ciclopentanos/metabolismo , Modelos Moleculares , Conformación Molecular , EstereoisomerismoRESUMEN
BACKGROUND: Face-lifting can result in a number of complications. A mini-invasive technique is now presented. OBJECTIVE: To perform face-lifting as a simple, quick, and mini-invasive ambulatory approach in patients requiring mild to moderate lift. MATERIALS AND METHODS: Using a Khawaja-Hernandez or Keith needle and polypropylene 2-0, the superficial SMAS is pulled up and fixed to the periosteum of the temporal bone. Nineteen patients were so operated on, 14 women and 5 men, whose ages varied from 51 to 67 years. Pre- and postoperative photographs were taken. The degree of satisfaction was measured from 1 to 3 (1 being the least satisfactory). Informed consent was signed by all of the patients. RESULTS: Satisfactory results were obtained in all cases. Patients enjoyed the ease of the procedure. CONCLUSION: This is a simple, quick, and noncomplicated way to perform a face-lift. It can be combined with other modalities of facial rejuvenation.