RESUMEN
In 22 subjects with liver cirrhosis and in 18 with malignancy, both with ascites, 10 biochemical parameters have been investigated in ascitic fluid. The evaluation of data by cluster analysis, optimized with the aid of multivariate normality testing, was able to recognize correctly a majority of cases. For diagnosis of malignancy, an 89% sensitivity and 82% specificity was obtained. The described way of data collecting and processing is recommended for the clinical practice.
Asunto(s)
Líquido Ascítico/metabolismo , Bioquímica , Cirrosis Hepática/diagnóstico , Neoplasias Hepáticas/diagnóstico , Fenómenos Bioquímicos , Análisis por Conglomerados , Diagnóstico Diferencial , Humanos , Neoplasias Peritoneales/secundarioRESUMEN
The authors investigated 24 patients with chronic infection with the hepatitis B virus. HBeAg-positive patients had significantly (alpha = 0.05) more frequently pathological initial values of biochemical and immunological indicators, as compared with anti-HBe-positive patients. Delta antigen in the liver and anti-delta antibodies in serum if examined, were always negative. All patients were subjected to 16-week treatment with Essentiale forte (Natterman). After treatment and after the subsequent 16 weeks in none of the patients loss of HBsAg or seroconversion of HBeAg-positive to anti-HBe-positive was recorded. In the sub-group of HBeAg-positive subjects after treatment a significant drop of gamma-globulins and circulating immunocomplexes occurred, in the sub-group of anti-HBe-positive subjects a significant rise of active and total T-lymphocytes was found. The authors recommend to test Essentiale forte in the prevention and treatment of immunocomplex disease in chronic infection with the hepatitis B virus.
Asunto(s)
Hepatitis B/tratamiento farmacológico , Fosfatidilcolinas/uso terapéutico , Adulto , Anciano , Enfermedad Crónica , Femenino , Hepatitis B/sangre , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The paper deals with the course of different forms of chronic hepatitis in pregnancy, as well as with the effect of chronic hepatitis on the course of gestation and on the fetus. Suggestions are put forward as to conditions which still agree and those which disagree with pregnancy when the woman already suffers from chronic hepatitis. The procedure of immunoprophylaxis of newborns from HBsAg-positive mothers is also presented.