RESUMEN

AIM: In this study, we aimed to investigate whether changes in cerebrovascular voltage-dependent calcium channels and non-selective cation channels contribute to the enhanced endothelin-1-mediated vasoconstriction in the delayed hypoperfusion phase after experimental transient forebrain ischaemia. METHODS: Experimental forebrain ischaemia was induced in Wistar male rats by a two-vessel occlusion model, and the cerebral blood flow was measured by magnetic resonance imaging two days after reperfusion. In vitro vasoreactivity studies, immunofluorescence and quantitative PCR were performed on cerebral arteries from ischaemic or sham-operated rats to evaluate changes in vascular voltage-dependent calcium channels, transient receptor potential canonical channels as well as endothelin-1 receptor function and expression. RESULTS: The expression of transient receptor potential canonical channels 1 and 6 in the vascular smooth muscle cells was enhanced and correlated with decreased cerebral blood flow two days after forebrain ischaemia. Furthermore, under conditions when voltage-dependent calcium channels were inhibited, endothelin-1-induced cerebrovascular contraction was enhanced and this enhancement was presumably mediated by Ca(2+) influx via upregulated transient receptor potential canonical channels 1 and 6. CONCLUSIONS: Our data demonstrates that endothelin-1-mediated influx of extracellular Ca(2+) activates transient receptor potential canonical channels 1 and 6 in cerebral vascular smooth muscle cells. This seems to have an important role in the enhanced cerebral vasoconstriction in the delayed post-ischaemic hypoperfusion phase after experimental forebrain ischaemia.

Asunto(s)

RESUMEN

There has recently been considerable interest in the use of nuclear magnetic resonance (NMR) as a technology for the implementation of small quantum computers. These computers operate by the laws of quantum mechanics, rather than classical mechanics and can be used to implement new quantum algorithms. Here we describe how NMR in principle can be used to implement all the elements required to build quantum computers, and draw comparisons between the pulse sequences involved and those of more conventional NMR experiments.

Asunto(s)

RESUMEN

When operated carelessly, snowblowers can produce serious trauma to the hand. During a 3-year period, 13 cases were identified. The injuries occurred when the operators attempted to dislodge impacted snow from the snowblower chute. Experience with the equipment did not appear to be a factor. The frequency of injuries was directly related to the depth of snowfall. Higher temperatures and wet snow were also important. The long and ring fingers of the dominant hand were most frequently injured. A total of 22 digits in 13 patients were involved. Three digits underwent amputation. All patients had fractures, ranging from simple closed fractures of the distal tuft to open comminuted fractures of the proximal phalanx. Injuries were treated with debridement and primary repair. Operator carelessness is usually responsible for the injury. If the public is made aware of snowblower hazards at the time of heavy snowfall, injuries may be avoided.

Asunto(s)

RESUMEN

A case of chronic digital synovitis and foreign body reaction secondary to metallic filings is reported. The patient had a digital mass and a previous history of a ring finger injury. A saw action ring remover was implicated as a source of foreign bodies produced by ring removal over the open wound. Care should be taken to avoid implantation of metal filings with this technique, and an alternate method of removing rings from injured fingers should be considered.

Asunto(s)

RESUMEN

A patient who has undergone successful replantation of seven of eight amputated digits is presented. Survival in the last viable digit was seen 39 hours after amputation with cold ischemia preservation. No graded ischemia-related changes in the digits have been appreciated over 35 months of follow-up.

Asunto(s)

RESUMEN

Agricultural accidents are a frequent cause of severe injury. Sixty-four patients with such injuries were seen from October 1981 through September 1984. The patients ranged in age from 2 to 73 years. The highest incidence of injury occurred during spring planting (May through June) and fall harvesting (September through October). The tractor and grain auger were the most common injuring agents. The upper extremity was the most common site of injury, followed by the lower extremity. Because such injuries are usually of a crushing nature and are heavily contaminated, extensive debridement and irrigation are essential in their care.

Asunto(s)

RESUMEN

Shortage of laboratory personnel appears to have created growing interest and activity in retraining inactive medical technologists. A recent three year program at the University of Wisconsin involving 63 individuals enrolled in one or more courses provides some results. Twenty-three are now employed, and nine are actively seeking employment. The development, presentation, evaluation and cost of the program are here reported.

Asunto(s)

RESUMEN

In the belief that there is an ongoing need for the retraining of inactive medical technologists, the University of Wisconsin-Madison initiated such a program in 1978. A model course in routine chemistry and instrumentation was developed, presented, and evaluated. This model is described in detail. Results indicate that most inactive medical technologists can regain competence. The program and individual courses are designed so they can be easily replicated or adapted for use by others interested in retraining inactive medical tehcnologists.

Asunto(s)

RESUMEN

The use of an external cranial device for endotracheal tube fixation can prevent mechanical dislodgement of skin grafts and permit easy access while one is operating on extensive burns of the face.

Asunto(s)

Asunto(s)

Asunto(s)

Asunto(s)

Asunto(s)

Asunto(s)

Asunto(s)

Asunto(s)

Asunto(s)