RESUMEN
China has implemented main functional areas planning (MFAP) since 2010, which is essential for improving the efficiency of land space utilization and achieving sustainable urban development. Quantitative assessments of the urban development levels (UDLs) at the county level across China after the implementation of MFAP have not been well-documented. In this study, a unified indicator system was developed, and the UDLs of 2850 counties in China after MFAP implementation were evaluated. The results showed that MFAP played a positive role in urban development in China. The UDLs in China generally increased but showed obvious spatial differences. The higher UDLs were mostly found in the counties in the five urban belts, which reflects the overall urban layout of China. The UDLs were generally low in the western counties in comparison with those in the eastern part of China. The differences in the UDLs from east to west were greater than those from north to south. Moreover, the differences in the UDLs presented a spatial agglomeration effect. This study could offer insight into the refinement of MFAP in China and sustainable urban development in developing countries.
Asunto(s)
Países en Desarrollo , Urbanización , China , Demografía , Geografía , Humanos , Población UrbanaRESUMEN
Background: Cathepsin C (CTSC) (dipeptidyl peptidase I, DPPI), is a member of the papain superfamily of cysteine proteases and involves in a variety of host reactions. However, the information of CTST in Chinese giant salamander (Andrias davidianus), an amphibian species with important evolutionary position and economic values, remained unclear. Results: The full-length salamander CTSC cDNA contained a 96 bp of 5'-UTR, a 1392 bp of ORF encoding 463 amino acids, and a 95 bp of 3'-UTR. The salamander CTSC possessed several sequence features similar to other reported CTSCs such as a signal peptide, a propeptide and a mature peptide. The active site triad of Cys, His and Asn were also found existing in salamander CTSC. Salamander CTSC mRNA was constitutively expressed in all the examined tissues with significantly variant expression level. The highest expression of CTSC was in intestine, followed with stomach, spleen, lung and brain. Following Aeromonas hydrophila infection for 12 h, salamander CTSC was significantly up-regulated in several tissues including lung, spleen, brain, kidney, heart, stomach and skin. Conclusion: CTSC plays roles in the immune response to bacterial infection, which provided valuable information for further studying the functions of CTSC in salamander.