RESUMEN
This study investigated the relationship between body mass index (BMI) and falls among community-dwelling elderly. Results indicate that obesity is associated with increased falls and there appears to be a sex-specific difference with obese men at higher risk of falling. Obesity is identified as a risk factor for falls in men. INTRODUCTION: The prevalence of falls, fall-related injuries, and obesity has increased over the last decade. The objectives of this study were to investigate sex-specific association and dose-response relationship between BMI and falls (and related injuries) among community-dwelling elderly. METHODS: Our study sample consisted of 15,860 adults aged 65 years or older (6399 men and 9461 women) from the 2008-2009 Canadian Community Health Survey-Healthy Aging (CCHS-HA). Falls, fall-related injuries, and BMI measures were self-reported. For both sex, dose-response curves presenting the relationship between BMI, falls, and fall-related injuries were first examined. Thereafter, multivariate logistic regression analyses were also performed to investigate these relationships after adjustment for potentially confounding variables. RESULTS: Of women, 21.7 % reported a fall and 16.9 % of men. The dose-response relationship between BMI and prevalence of falls showed that underweight and obese individuals reported falling more than normal and overweight individuals; this being more apparent in men than women. Finally, the dose relationship between BMI and prevalence of fall-related injuries showed that only obese men seem more likely to have sustained a fall-related injury. Results from the multivariate analysis showed that obesity in men was significantly associated with higher odds of falling odds ratio (OR) 1.33 (1.04-1.70) and was not significantly associated with higher odds of fall-related injuries OR 1.10 (0.66-1.84) over a 12-month period compared to normal weight men. For women, obesity was not significantly associated with higher fall prevalence OR 0.99 (0.79-1.25) and fall-related injuries OR 0.71 (0.51-1.00). CONCLUSION: Obesity is associated with self-reported falls, and there appears to be a sex-specific difference in elderly persons.
Asunto(s)
Accidentes por Caídas/estadística & datos numéricos , Obesidad/epidemiología , Heridas y Lesiones/epidemiología , Distribución por Edad , Anciano , Índice de Masa Corporal , Canadá/epidemiología , Comorbilidad , Atención a la Salud/estadística & datos numéricos , Femenino , Encuestas Epidemiológicas , Humanos , Vida Independiente , Masculino , Obesidad/complicaciones , Obesidad/fisiopatología , Prevalencia , Autoinforme , Distribución por Sexo , Heridas y Lesiones/etiologíaRESUMEN
Rectal (T(re)), ear canal (T(ear)) and esophageal (T(es)) temperatures have been used in the literature as core temperature indices in humans. The aim of the study was to investigate if localized lower body cooling would have a different effect on each of these measurements. We hypothesized that prolonged lower body surface cooling will result in a localized cooling effect for the rectal temperature not reflected in the other core measurement sites. Twelve participants (mean ± SD; 26.8 ± 6.0 years; 82.6 ± 13.9 kg; 179 ± 10 cm, BSA = 2.00 ± 0.21 m(2)) attended one experimental session consisting of sitting on a rubberized raft floor surface suspended in 5 °C water in a thermoneutral air environment (approximately 21.5 ± 0.5 °C). Experimental conditions were (a) a baseline phase during which participants were seated for 15 min in an upright position on an insulated pad (1.408 K â m(2) â W(-1)); (b) a cooling phase during which participants were exposed to the cooling surface for 2 h, and (c) an insulation phase during which the baseline condition was repeated for 1 h. Temperature data were collected at 1 Hz, reduced to 1 min averages, and transformed from absolute values to a change in temperature from baseline (15 min average). Metabolic data were collected breath-by-breath and integrated over the same temperature epoch. Within the baseline phase no significant change was found between the three indices of core temperature. By the end of the cooling phase, T(re) was significantly lower (Δ = -1.0 ± 0.4 °C) from baseline values than from T(ear) (Δ = -0.3 ± 0.3 °C) and T(es) (Δ = -0.1 ± 0.3 °C). T(re) continued to decrease during the insulation phase from Δ -1.0 ± 0.4 °C to as low as Δ -1.4 ± 0.5 °C. By the end of the insulation phase T(re) had slightly risen back to Δ -1.3 ± 0.4 °C but remained significantly different from baseline values and from the other two core measures. Metabolic data showed no variation throughout the experiment. In conclusion, the local cooling of the buttock area results in a drop in rectal temperature compromising the validity of the rectal temperature as a core temperature index under these conditions.
Asunto(s)
Regulación de la Temperatura Corporal , Adulto , Conducto Auditivo Externo/fisiología , Esófago/fisiología , Humanos , Recto/fisiología , Reproducibilidad de los Resultados , Factores de TiempoRESUMEN
OBJECTIVE: Overweight individuals sway more than normal weight individuals. Major weight loss improves their balance control despite a related decrease in muscle strength. Presumably, muscular strength is an important factor for balance control. This study investigated the effect that a change in body mass has on relative strength and balance control. METHODOLOGY: Force (isometric knee extension) and balance control (center of pressure speed and range) were studied in three groups; normal weight (BMI <25 kg m(-2)), obese (30 kg m(-2)
Asunto(s)
Fuerza Muscular/fisiología , Obesidad/fisiopatología , Equilibrio Postural/fisiología , Pérdida de Peso/fisiología , Adulto , Análisis de Varianza , Cirugía Bariátrica , Fenómenos Biomecánicos , Índice de Masa Corporal , Restricción Calórica , Humanos , Masculino , Obesidad/cirugíaRESUMEN
An unbiased, polygenic approach is needed to unravel the complex molecular bases of craniofacial development and disease. DNA microarrays, the current paradigm of genome-wide analysis, permit the simultaneous study of many thousands of genes, the ready identification of candidate molecules and pathways, and the compilation of gene expression profiles for whole systems--pathologic and embryonic alike. We survey the existing literature applying microarrays to craniofacial biology and highlight the value of animal models, particularly mice and chickens, to understanding molecular regulation in the craniofacial complex. We also emphasize the importance of functional studies and high-throughput assays to extracting useful data from microarray output. It is our goal to help put researchers and clinicians on the same page as microarray technology moves into the forefront of craniofacial biology.