RESUMEN
This article covers the methodology used for calculating reproduction and production performance for the Standardized Performance Analysis (SPA) reports. Computation, limitations, and interpretations of each measurement are discussed.
Asunto(s)
Crianza de Animales Domésticos/normas , Bovinos , Agricultura/normas , Agricultura/estadística & datos numéricos , Animales , Bovinos/crecimiento & desarrollo , Bovinos/fisiología , Femenino , Masculino , Control de Calidad , Estándares de Referencia , Reproducción/fisiología , Estados UnidosRESUMEN
The concentrations of C3d in the plasma and of C-reactive protein (CRP), immune complexes and rheumatoid factor in the serum were measured in 99 patients with rheumatoid arthritis. Most patients had raised levels, the values of which correlated with disease activity assessed according to a newly described index based on multivariate analysis of subjective, semi-objective and objective features of the disease. There were also significant correlations between the values for plasma C3d and circulating immune complexes, immune complexes and rheumatoid factor, serum CRP and immune complexes, and serum CRP and plasma C3d. Measurement of plasma C3d provides a useful means of detecting in vivo complement activation, which may be involved in the pathogenesis of rheumatoid arthritis, but neither C3d levels nor any of the other variables correlated as closely with disease activity as did the serum CRP concentration.
Asunto(s)
Complejo Antígeno-Anticuerpo/análisis , Artritis Reumatoide/inmunología , Proteína C-Reactiva/metabolismo , Complemento C3/metabolismo , Factor Reumatoide/metabolismo , Adulto , Anciano , Artritis Reumatoide/fisiopatología , Activación de Complemento , Complemento C3d , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Serum C-reactive protein (CRP) levels were measured in 99 patients with definite or classical rheumatoid arthritis (RA). At the same time as the serum was obtained, the activity of the RA was assessed by assigning scores to a comprehensive set of subjective, semi-objective and objective clinical features. The results confirmed that the serum CRP concentration closely reflects activity of RA and is of value in its objective assessment. Erythrocyte sedimentation rate (ESR) followed the same pattern as CRP levels but all of the subjective and semi-objective criteria correlated more significantly with CRP levels than with ESR.