RESUMEN
This paper suggests that changes in temporal constructs and disjunctures between the 'technical time' perspective of Canadian Arctic settlements and the indigenous cyclical and linear temporal orientation of Inuit peoples relate to increasing incidence of psycho- and sociopathologies in these communities. It argues that loss of community integration through the replacement of Inuit historical linear time perspectives by Eurocanadian settlement history, and dissociation from the land and its seasonally cyclical migratory and exploitive patterns are of particular significance for the younger, settlement-born, temporally marginalized Inuit who constitute the highest risk population for mental ill-health.
Asunto(s)
Inuk/psicología , Salud Mental , Alcoholismo , Regiones Árticas , Canadá , Comercio , Características Culturales , Historia del Siglo XX , Humanos , Inuk/historia , Cambio SocialRESUMEN
A new rapid assay has been developed for measurement of the binding of [3H]retinoic acid to cellular retinoic acid-binding protein. The assay, which uses activated charcoal for the separation of bound from unbound retinoic acid, was used to determine the concentration required to inhibit the binding of [3H]retinoic acid to cellular retinoic acid-binding protein by 50% for 18 retinoids with free carboxylic acid groups. Partially purified cellular retinoic acid-binding proteins isolated from rat testes and carcinogen-induced rat mammary tumors were used for these determinations. The following parameters were also determined for some or all of the retinoids: hypervitaminosis A doses; activity against carcinogen-induced mouse skin papillomas; inhibition of growth of a rat chondrosarcoma; inhibition of growth of 3T6 cells; and differentiation of the embryonal carcinoma cell line PCC4.azaIR. While all retinoids that are potent in these biological test systems bind tightly to cellular retinoic acid-binding protein, the converse is not true. The lack of a consistent quantitative correlation between 50% inhibitory concentration and biological activity is probably due to insufficient concentrations of the retinoid in the target tissue or celll, which is a consequence of factors such as absorbability, metabolism, tissue distribution, and pharmacokinetics.