RESUMEN

This study examined forearm vasodilatation during mental challenge and exercise in 72 obese children (OC; age = 10 +/- 0.1 years) homozygous with polymorphism in the allele 27 of the beta-2-adrenoceptors: Gln27 (n = 61) and Glu27 (n = 11). Forearm blood flow was recorded during 3 min of each using the Stroop color-word test (MS) and handgrip isometric exercise. Baseline hemodynamic and vascular measurements were similar. During the MS, peak forearm vascular conductance was significantly greater in group Glu27 (Delta = 0.35 +/- 0.4 vs. 0.12 +/- 0.1 units, respectively, p = .042). Similar results were found during exercise (Delta = 0.64 +/- 0.1 vs. 0.13 +/- 0.1 units, respectively, p = .035). Glu27 OC increased muscle vasodilatory responsiveness upon the MS and exercise.

Asunto(s)

Cognición , Ejercicio Físico , Músculo Esquelético/metabolismo , Obesidad/metabolismo , Polimorfismo Genético , Receptores Adrenérgicos beta 2/genética , Vasodilatación , Antropometría , Índice de Masa Corporal , Niño , Protección a la Infancia , Prueba de Esfuerzo , Femenino , Antebrazo/irrigación sanguínea , Fuerza de la Mano , Hemodinámica , Humanos , Masculino , Obesidad/fisiopatología , Psicometría , Receptores Adrenérgicos beta 2/metabolismo , Estrés Psicológico