RESUMEN
Development of biobanks is still hampered by difficulty to collect high quality sample annotations using patient clinical information. The IBCB project evaluated the feasibility of a nationwide clinical data research network for this purpose. METHOD: the infrastructure, based on eHOP and I2B2 technologies, was interfaced with the legacy IT components of 3 hospitals. The evaluation focused on the data management process and tested 5 expert queries in Hepatocarcinoma. RESULTS: the integration of biobank data was comprehensive and easy. Five out of 5 queries were successfully performed and shown consistent results with the data sources excepted one query which required to search in unstructured data. The platform was designed to be scalable and showed that with few effort biobank data and clinical data can be integrated and leveraged between hospitals. Clinical or phenotyping concepts extraction techniques from free text could significantly improve the samples annotation with fine granularity information.
Asunto(s)
Bancos de Muestras Biológicas , Almacenamiento y Recuperación de la Información , Hospitales , Humanos , Investigación , Programas InformáticosRESUMEN
BACKGROUND: The effects of physical exercise on the cardiovascular system are presented as a 'paradox' with beneficial effects and hazards. Most earlier studies were retrospective, were concerned with trained athletes, and focused on sudden death or myocardial infarction (MI). The aim of this study was to prospectively study the incidence and the causes of sports-related acute cardiovascular events in a general population. DESIGN AND METHOD: This 1-year prospective study concerned three regions of the southwest of France. Four hospital medical emergency departments participated in the study, and collected all cases of sports-related acute cardiovascular events. RESULTS: One hundred and twenty-seven sports-related cardiovascular events were collected. The mean age of the participants was 45.5 (14.6) years. Most of the events involved men (81.1%). Thus, global incidence of sports-related acute cardiovascular events was 6.5/100,000 participants/year and 10.8/100,000 men/year and 2.2/100,000 women/year, respectively. Forty sports-related deaths [49.0 (13.9) years old; 38 men], 47 sports-related nonlethal MI [52.8 (10.7) years old; 42 men], and 32 (21 men) sports-related cardiac arrhythmias (21 supraventricular, 10 men) were reported. Sports-related deaths and MI were most often observed in the 35-59-years-old men group (P = 0.01). Running, cycling, and swimming were mainly concerned. CONCLUSION: In the general population studied, the absolute incidence of sport-related acute cardiovascular events comprised 6.5/100,000 participants/year. Sports-related MI and deaths, which were the two main causes of emergency calls, were significantly more frequent in middle-aged men. In all cases, except for sports-related supraventricular arrhythmias, men were significantly more involved than women.