RESUMEN

<p><b>OBJECTIVE</b>To elvaulate the antioxidant activity of the pigment of Lycium ruthenicum.</p><p><b>METHOD</b>The antioxidant activities were measured by the effects of the reducing ability, scavenging DPPH. H2O2-induced hemolysis of mice erythrocyte, serum resistance of reactive oxygen species, content of MDA in liver tissue, and swelling effect of mitochondria in liver tissue.</p><p><b>RESULT</b>The pigment of L. ruthenicum could scaveng DPPH* remarkably with IC50 0.164 mg x mL(-1), inhibitte hemolysis of mice erythrocyte evidently with IC50 0.112 mg x mL(-1). The resistant of reactive oxygen species was enhanced by the tested substances, simultanously. The concentration of MDA of peroxidation of lipid in mice liver could be reduced, and the swelling of mice liver mitochondria alse be restrained.</p><p><b>CONCLUSION</b>The pigment of L. ruthenicum has antioxidant activity in tested concentration.</p>

Asunto(s)

Animales , Ratones , Antioxidantes , Farmacología , Compuestos de Bifenilo , Metabolismo , Eritrocitos , Depuradores de Radicales Libres , Farmacología , Hemólisis , Hidrazinas , Metabolismo , Peroxidación de Lípido , Hígado , Metabolismo , Lycium , Química , Malondialdehído , Metabolismo , Mitocondrias Hepáticas , Patología , Dilatación Mitocondrial , Fenoles , Farmacología , Picratos , Pigmentos Biológicos , Farmacología , Plantas Medicinales , Química , Especies Reactivas de Oxígeno