RESUMEN
We describe a case of reversible dementia caused by Tropheryma whippelii (TW). Diagnosis was confirmed by a positive polymerase chain reaction for this pathogen both on serum and cerebrospinal fluid. Specific antibiotic therapy resulted in distinct clinical and neuroradiological improvement. Control polymerase chain reaction for T. whippelii on serum and cerebrospinal fluid was negative.
Asunto(s)
Infecciones del Sistema Nervioso Central/complicaciones , Demencia/microbiología , Enfermedad de Whipple/complicaciones , Anciano , Antibacterianos , Infecciones del Sistema Nervioso Central/tratamiento farmacológico , Quimioterapia Combinada/uso terapéutico , Femenino , Humanos , Inducción de Remisión , Combinación Trimetoprim y Sulfametoxazol/uso terapéutico , Enfermedad de Whipple/tratamiento farmacológicoRESUMEN
SUMMARY: When Whipple disease (WD) is confined to the CNS, diagnosis may be difficult. We report a case of WD with spinal presentation in an otherwise healthy woman who had a 5-year history of relapsing-remitting cervico-thoracic myelopathy. We suggest that the diagnosis of WD should be considered in the presence of an enlarged and enhancing spinal cord even in the absence of any systemic involvement.