RESUMEN

Ultra-compliant neural probes implanted into tissue using a molded, biodissolvable sodium carboxymethyl cellulose (Na-CMC)-saccharide composite needle delivery vehicle are subjected to fluid-structure interactions that can displace the recording site of the probe with respect to its designed implant location. We applied particle velocimetry to analyze the behavior of ultra-compliant structures under different implantation conditions for a range of CMC-based materials and identified a fluid management protocol that resulted in the successful targeted depth placement of the recording sites.

Asunto(s)

Encéfalo/fisiología , Fenómenos Mecánicos , Polímeros/química , Reología , Animales , Carboximetilcelulosa de Sodio/química , Bovinos , Glucosa/administración & dosificación , Microscopía Fluorescente , Agujas , Imagen Óptica , Solubilidad , Grabación en Video