1.
Bioorg Med Chem Lett
; 9(6): 895-900, 1999 Mar 22.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10206557
RESUMEN
A novel scaffold for P4-P2 dipeptide mimics containing a rigid pyridone spacer was designed based on a virtual library strategy. Several selected nonpeptidic 4-aralkyl or 4-alkylpyridones incorporating a P1-argininal sequence were prepared. The modeling studies, synthesis and biological activities of these unique pyridone derivatives are reported herein.
Asunto(s)
Arginina/química , Piridonas/síntesis química , Trombina/antagonistas & inhibidores , Trombina/química , Factor Xa/farmacología , Fibrinolisina/farmacología , Concentración 50 Inhibidora , Cinética , Modelos Químicos , Tripsina/farmacología
2.
J Med Chem
; 39(23): 4531-6, 1996 Nov 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-8917639