RESUMEN
Operations on lumbar disc prolapses are the most frequent operations in German neurosurgery divisions. After such operations, spondylodiscitis is a dreaded complication which is sometimes difficult to diagnose. Treatment of spondylodiscitis is always protracted and a burden for doctors and patients. Hence, it appears worthwhile to present a further report on discitis and spondylodiscitis, infections of the intervertebral space and the surrounding tissues after disk operations. Various clinical pictures are described: septic progress forms with neurological disorders and the necessity of open wound treatment as well as clinical pictures without septic signs with good recovery after immobilisation and antibiotic treatment. In two cases, CT-guided puncture of purulent suppuration with identification of the causative organisms and specific antibiotic treatment was possible. All patients had a relatively good result: pareses and/or bladder/rectal disorders disappeared completely in every case. The causes of discitis are discussed. The condition arises when nosocomial microorganisms, or very frequently even harmless skin bacteria, enter the wound. A large number of operations are carried out under pressure of time and under hectic conditions, as well as in a confined space in operation theatres which are too warm; these factors increase the susceptibility to infection. However, the resistance of the patient to infection is also weakened after longterm prior antiinflammatory treatment and a stay in hospital before the operation. Besides appropria to treatment of the infection (immobilisation, wound treatment, antibiotic therapy), psychological management of the patient is an important component of therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Infección Hospitalaria/cirugía , Desplazamiento del Disco Intervertebral/cirugía , Vértebras Lumbares/cirugía , Infección de la Herida Quirúrgica/cirugía , Adulto , Infección Hospitalaria/diagnóstico , Femenino , Humanos , Desplazamiento del Disco Intervertebral/diagnóstico , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Recurrencia , Reoperación , Infección de la Herida Quirúrgica/diagnóstico , Tomografía Computarizada por Rayos XAsunto(s)
Infecciones Bacterianas/microbiología , Infecciones Urinarias/microbiología , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Infecciones Bacterianas/tratamiento farmacológico , Clotrimazol/farmacología , Farmacorresistencia Microbiana , Enterobacteriaceae/efectos de los fármacos , Enterobacteriaceae/aislamiento & purificación , Femenino , Humanos , Masculino , Ácido Nalidíxico/farmacología , Especificidad de la Especie , Staphylococcus aureus/efectos de los fármacos , Staphylococcus aureus/aislamiento & purificación , Streptococcus/efectos de los fármacos , Streptococcus/aislamiento & purificación , Infecciones Urinarias/tratamiento farmacológico , Orina/microbiologíaRESUMEN
Strains of staphylococci sensitive and resistant to ampicillin were examined in their resistance to oxacillin, propicillin and penicillin G. For all the examined strains oxacillin showed values in the range of sensitiveness, propicillin proved itself distinctly more active in vitro than penicillin G resp. V. The satisfactory pharmacokinetic properties and the higher stability against penicillinase might result in an increased therapeutical security of the treatment with propicillin compared with penicillin V.
Asunto(s)
Penicilinas/farmacología , Staphylococcus aureus/efectos de los fármacos , Humanos , Pruebas de Sensibilidad Microbiana , Oxacilina/farmacología , Penicilina G/farmacología , Penicilina V/análogos & derivados , Penicilina V/farmacologíaRESUMEN
The in vitro sensitivity of tetracycline and doxycycline is compared. Streptococcus and staphylococcus are more sensitive to doxycycline whereas pseudomonas and proteus spec. are more sensitive to tetracycline.
Asunto(s)
Doxiciclina/farmacología , Farmacorresistencia Microbiana , Tetraciclina/farmacología , Enterococcus faecalis/efectos de los fármacos , Escherichia coli/efectos de los fármacos , Alemania Occidental , Técnicas In Vitro , Proteus/efectos de los fármacos , Pseudomonas aeruginosa/efectos de los fármacos , Staphylococcus aureus/efectos de los fármacosRESUMEN
The polymorphism of glyoxalase I was investigated in 169 mother-child combinations from southwestern Germany. Glyoxalase I (GLO) has 3 common phenotypes: GLO 1, GLO 2-1, and GLO 2. The results are in good agreement with the formal hypothesis: Two alleles GLO1 and GLO2 at an autosomal locus. The GLO1 gene frequency was estimated to be 0.39. From the electrophoretic pattern the GLO-molecule appears to consist of two subunits.
Asunto(s)
Eritrocitos/enzimología , Liasas , Polimorfismo Genético , Femenino , Frecuencia de los Genes , Alemania Occidental , Glutatión , Glioxal , Humanos , Biología MolecularRESUMEN
The polymorphism of the human phosphoglucomutase isozyme PGM3 can be demonstrated in erythrocyte hemolysates by means of horizontal starch gel electrophoresis. Gene frequencies from southwestern Germany are given. The frequency of the allel PGM-23 was estimated to be 0.232.