RESUMEN

Hepatoprotective effects of granulocytic CSF were studied using experimental model of CCl4-induced hepatitis. It was found that treatment with granulocytic CSF increased the content of stromal precursors and mesenchymal stem cells in the bone marrow and peripheral blood with subsequent increase in the number of hepatic precursor cells in the liver. These findings attest to mobilization of progenitor mesenchymal cells and their migration into damages liver tissue, which accelerates its regeneration related to changes in the parenchyma, but not connective tissue development.

Asunto(s)

Tetracloruro de Carbono/toxicidad , Factor Estimulante de Colonias de Granulocitos/metabolismo , Hepatitis/tratamiento farmacológico , Hígado/efectos de los fármacos , Animales , Células de la Médula Ósea/citología , Femenino , Hepatitis/metabolismo , Hígado/metabolismo , Masculino , Mesodermo/metabolismo , Ratones , Ratas , Ratas Wistar , Células Madre/citología , Células Madre/metabolismo , Cicatrización de Heridas