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@#ObjectiveTo compare the clinical characteristics of AQP4-IgG-positive and AQP4-IgG-negative optic neuromyelitis spectrum disease（NMOSD） patients. MethodsClinical data of 345 NMOSD patients admitted to the First Affiliated Hospital of Zhengzhou University from September 2015 to September 2019 were collected. According to the serological status of AQP4-IgG，NMOSD patients were divided into AQP4-IgG positive group and AQP4-IgG negative group. ResultsThere were 244 cases in the AQP4-IgG positive group and 101 cases in the AQP4-IgG negative group，respectively. The female，anti-nuclear antibody spectrum and other autoimmune diseases in the AQP4-IgG positive group were significantly higher than those in the negative group（P=0.000；P=0.000；P=0.003），the incidence of brain lesions，optic neuritis，both optic neuritis and myelitis in AQP4-IgG negative group were significantly higher than those in the positive group（P=0.000；P=0.000；P=0.012）；The utilization of immunosuppressive agents in the AQP4-IgG positive group was significantly higher than that in the negative group（P=0.025）. In addition，vitamin B-12 and ESR were significantly higher in the AQP4-IgG positive group than in the negative group（P=0.015；P=0.009）；The homocysteine and hemoglobin in AQP4-IgG negative group were significantly higher than those in the positive group（P=0.009；P=0.002）. The incidence of myelitis，the segments of myelopathy，lumbar spinal lesions，supratententinal lesions，the total number of attacks，follow-up time，the lowest and the last follow-up EDSS showed no statistical difference between AQP4-IgG positive group and negative group（P>0.05），there were no statistically differences in age，C-reactive protein，leukocyte，platelet，the ratio of white blood cell and lymphocyte，protein in CSF between the two groups（P>0.05）. ConclusionThere are many differences in clinical disease characteristics between AQP4-IgG positive and negative NMOSD patients. Optic neuritis，brain lesions and simultaneous involvement of optic nerve and spinal cord were more common in AQP4-IgG negative patients，the hemoglobin and homocysteine were significantly higher. Female，antinuclear antibody profiles，and other autoimmune diseases were more common in AQP4-IgG positive patients，who with higher vitamin B12 and ESR.
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Objective:To investigate the radionuclide concentrations in rice and corn in some areas of Yunnan province, and enrich the baseline data on radioactivity level in food in Yunnan province, and assess the health risks to residents.Methods:The samples of rice and corn collected from 20 counties in Yunnan province were determined by using gamma spectrometer under the national standards Gamma Spectrometry Method of Analysing Radionuclides In Biological Samples (GB/T 16145-1995), General Analytical Method of High-Purity Germanium Gamma Spectrometer (GB/T 11713-2015), Examination of Radioactive Materials for Foods- General Principle (GB 14883.1-2016) and Determination of Radionuclides in Soil by Gamma Spectrometry(GB/T11743-2013). The results were compared and evaluated.Results:The average activity concentrations in rice were found to be 238U (0.416±0.403) Bq/kg, 32Th (0.045±0.034) Bq/kg, 226Ra (0.030±0.013) Bq/kg, 40K (28.4±18.8) Bq/kg and 137Cs (0.014±0.019) Bq/kg, respectively, and in corn to be 238U (0.308±0.230) Bq/kg, 232Th (0.035±0.031) Bq/kg, 226Ra (0.053±0.072) Bq/kg, 40K (56.8±38.6) Bq/kg, respectively. The specific activities of the 137Cs were lower than the detection lower limit. Conclusions:The radionuclide concentration of 238U, 232Th, 226Ra, 40K and 137Cs in rice and corn in 20 counties of Yunnan province meets the national standards. The dose burden to the public will not affect human health.
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Objective To investigate the radioactivity levels in foods in environmental protection area around a decommissioned uranium mine in Yunnan province,in order to timely discover the release of radioactive substances and to provide accumulated baseline data.Methods Radioactivity levels in grains,vegetables and fresh tea at 20 sampling points were measured in the environmental protection area within 3 km of a decommissioned the uranium mine.After field pretreatment and laboratory preparation,the radionuclides in samples were analyzed by means of γ spectrometry.Results Radionuclides in foods in the area mainly include natural radionuclides (238 U,232Th,226Ra,40 K) and man-made radionuclide (137 Cs).Radioactivity level of 238U,232Th,226Ra and 40K was (0.17 ± 0.05),(0.25 ± 0.17),(0.43 ±0.28)and (103.49 ±25.10)Bq/kg(fresh weight),respectively.Radioactivity levels of 232Th,226Ra,40K and 137Cs in fresh tea were all higher than those in grains and vegetables.Conclusions Radioactivity levels in foods around the area are lower than the relevant national limits.No man-made radionuclide other than 137Cs was found in the area.
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With the application of robotic-assisted arthroplasty in the clinical setting during the last two decades,passive,semiautonomous,and autonomous surgical robotic systems have been developed and utilized in a wide range of surgical procedures.Such procedures include total hip arthroplasty,total knee arthroplasty,and unicompartmental knee arthroplasty.These robotic platforms can be divided into open platforms and closed systems.A navigation component is indispensable for all kinds of surgical robotic systems used in arthroplasty.Navigation components need two disparate approaches to realize three-dimensional reconstruction.Some robotic systems require preoperative imaging examination for navigation,while others only need intraoperative anatomic landmark identification.The following four types of FDA-approved surgical robotic systems are currently available for arthroplasty,the Robodoc autonomous system,the Rio haptic system,the iBlock cutting guide,and the Navio handheld system.Robotic-assisted arthroplasty reportedly facilitates more accurate milling,cutting,and drilling,allowing component aligument and bone morphing to be performed with higher precision and closer to preoperative planning.These advantages result in better postoperative function restoration and patient satisfaction.The learning curve is also acceptable for these systems.Nonetheless,robotic systems are still somewhat disappointing,because they are typically associated with prolonged surgical procedures and require adequate surgical field exposure.Moreover,the cost-effectiveness ratio of this technology in China is required for further investigation.Future designs of robotic arthroplasty systems should aim to overcome the current shortcomings in terms of security and reliability,facilitating further automation of more surgical procedures and reduction in the size of the systems.
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Sexual function was studied in 48 male Type II diabetics together with 9 normal males as controls, all cases except 5 had various degrees of sexual dysfunction, which occurred predominatingly after, simultaneously with or before the onset of diabetic symptoms.The levels of plasma testosterone in diabetics were lower, and the plasma estradiol levels were higher than that of controls (p