RESUMEN
Selenium (Se)-rich farmland is a valuable and nonrenewable resource for addressing the global challenge of Se deficiency. However, frequent warnings of heavy metal pollution have threatened the safety and legitimacy of Se-rich functional agriculture, eventually damaged public health security. Definitive and judgmental quantitative studies on this hazardous phenomenon are still missing. Relevant reviews published in the past have summarized textual descriptions of the problem, lacking the support of the necessary statistical analysis of the data. Based on the collected publications, the present study evaluated and analyzed the sources, risks and impacts of heavy metal pollution in Se-rich farmland. Concentrations of cadmium (Cd), arsenic, lead and zinc in Se-rich farmland were significantly higher than those in non-Se-rich farmland, especially Cd. Pollution source analyses indicated that Se enrichment and heavy metal pollution occurred simultaneously in farmland, related to Se-heavy metal homology in rocks. According to environmental risk assessment, both serious Cd pollution and the narrow Se concentration range of safety utilization limited the availability of Se-rich farmland. Pollution impact predictions showed that the pollution in Se-rich farmland would result in serious human health risks to consumers and economic losses of 4000 yuan/hm2 on production side. Tackling Cd pollution was anticipated to recover economic losses (81 %) while lowering the carcinogenic (60 %) and non-carcinogenic (10 %) health risks. Our study also provided recommendations to address heavy metal pollution in Se-rich farmland. The two criteria should be followed by pollution control strategies applied to Se-rich functional agriculture including (i) not affecting the original Se enrichment in plant and (ii) not being interfered by Se in soil-plant systems. This will provide valuable information for Se-rich functional agriculture and public health security.
Asunto(s)
Agricultura , Monitoreo del Ambiente , Granjas , Metales Pesados , Selenio , Contaminantes del Suelo , Metales Pesados/análisis , Medición de Riesgo , Selenio/análisis , Contaminantes del Suelo/análisis , Humanos , Cadmio/análisis , Contaminación Ambiental/estadística & datos numéricosRESUMEN
Selenium (Se) deficiency in rice will result in a Se hidden hunger threat to the general public's human health, particularly in areas where rice consumption is high. Nevertheless, the impact scope and coping strategies have not been given sufficient focus on a worldwide scale. In order to evaluate the impacts, causes and biofortification strategies of Se-deficient rice, this study collected data from the publications on three themes: market survey, field sampling and controlled experiments. According to the market survey, global rice Se concentrations were 0.079 mg/kg on mean and 0.062 mg/kg on median. East Asia has a human Se intake gap due to the region's high rice consumption and the lowest rice Se concentration in markets globally. Total Se concentrations in East Asian paddy soils were found to be adequate based on the field sampling. However, over 70 % of East Asian paddy fields were inadequate to yield rice that met the global mean for rice Se concentration. The Se-deficient rice was probably caused by widespread low Se bioavailability in East Asian paddy fields. There were two important factors influencing rice Se enrichment including root Se uptake and iron oxide in soils. Concentrating on these processes is beneficial to rice Se biofortification. Since Se is adequate in the paddy soils of East Asia. Rather of adding Se exogenously, activating the native Se in paddy soil is probably a more appropriate strategy for rice Se biofortification in East Asia. Meta-analysis revealed water management had the greatest impact on rice Se biofortification. The risks and solutions for rice Se deficiency were discussed in our farmland-to-table survey, which will be a valuable information in addressing the global challenge of Se hidden hunger. This study also provided new perspectives and their justifications, critically analyzing both present and future strategies to address Se hidden hunger.
Asunto(s)
Desnutrición , Oryza , Selenio , Humanos , Selenio/análisis , Biofortificación , SueloRESUMEN
Enhanced rock weathering (ERW) in farmland is an emerging carbon dioxide removal technology with crushed silicate rocks for soil improvement. However, due to climatic variability and field data limitations, uncertainties remain regarding the influence of ERW on food security and soil carbon pools in temperate regions. This study focused to evaluate the crop productivity and carbon sequestration potential of farmland ERW in China by conducting field monitoring in different humid regions and ERW performance model. Additionally, the contribution of climate, soil, and management factors to ERW-mediated yield and carbon sequestration changes was explored using random forest and correlation networks. Field monitoring indicated that farmland ERW significantly improved crop yield in humid region (13.5 ± 5.2 %), along with notable improvements in soil pH and available nutrients. Precipitation (10.4-16.7 %) and soil pH (9.7-16.8 %) had the highest contribution on ERW mediated yield and carbon sequestration changes, but the contribution of management factors (24-26.2 %), especially N input (2.7-7.0 %), should not be disregarded. The model evaluation demonstrated that the carbon sequestration rate of farmland ERW in China can reach 0.28-0.40 Gt yr-1, thereby presenting an opportunity to expand and accelerate the nationally determined contributions of China. The mean sequestration cost of farmland ERW was 633 ± 161 CNY ¥ t-CO2-1, which was an attractive sequestration price considering the positive benefits of rock powder on soil pH and nutrients. Deploying ERW in acidified and mineral nutrient deficient regions was able to serve as an alternative to lime and part chemical fertilizers to improve yield and maximize agricultural sustainability and resource co-benefits. Farmland ERW also has the potential to resource silicate waste to assist traditional, difficult-to-decarbonize industries to reduce carbon emissions. As a result, a comprehensive assessment of existing artificial silicate waste materials could further expand the application of farmland ERW.
RESUMEN
OBJECTIVES: To evaluate the dosimetry, efficacy, and safety of radioactive 125I seed implantation (RISI) assisted by three-dimensional printing noncoplanar template (3D-PNCT) and CT for recurrent retroperitoneal lymphatic metastasis (RRLM) after previous external beam radiotherapy. METHODS AND MATERIALS: From June 2016 to August 2018, 32 patients with RRLM successfully underwent 3D-PNCT-assisted and CT-guided RISI. The dosimetry, pain relief rate, performance improvement rate, overall response rate, disease control rate, local control time (LCT), overall survival (OS), and safety profiles were evaluated. RESULTS: Dosimetric results showed that the D90, D100, V100, V150, V200, and homogeneity index were consistent in preoperation and postoperation (p > 0.05), except for the external index and conformal index (p = 0.048, p = 0.034). After RISI, 81.3% of the patients achieved pain relief, and 71.9% achieved an improvement of performance. The overall response rate and disease control rate were 85.3% and 94.1%, respectively. The LCT rates reached 66.2% and 43.2% in 1 year and two years, respectively, with a median LCT of 15.8 months. The OS rates were 74.1% and 28.1% in 1 year and two year, respectively, with a median OS reaching 17.6 months. Univariate analysis showed that when D90 > 130 Gy or D100 > 63 Gy or tumor size ≤49.8 cm3, LCT was extended significantly, but not for OS. Except for two patients developing Grade 1 retroperitoneal hematomas, no other severe adverse events were observed. CONCLUSIONS: 3D-PNCT and CT guidance provide excellent accuracy for RISI, which can be an effective and safe alternative for RRLM after external beam radiotherapy. Radiation dose and tumor size seem to significantly influence the local control.
Asunto(s)
Braquiterapia/instrumentación , Hematoma/etiología , Metástasis Linfática/radioterapia , Recurrencia Local de Neoplasia/radioterapia , Espacio Retroperitoneal , Adulto , Anciano , Braquiterapia/efectos adversos , Dolor en Cáncer/radioterapia , Femenino , Humanos , Radioisótopos de Yodo/uso terapéutico , Ganglios Linfáticos/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Periodo Posoperatorio , Impresión Tridimensional , Dosificación Radioterapéutica , Planificación de la Radioterapia Asistida por Computador , Retratamiento , Tasa de Supervivencia , Tomografía Computarizada por Rayos XRESUMEN
OBJECTIVES: The objective of this study was to evaluate the efficacy and safety of CT-guided radioactive 125I seed implantation as a salvage treatment for locally recurrent head and neck soft tissue sarcoma (HNSTS) after surgery and external beam radiotherapy. METHODS AND MATERIALS: From December 2006 to February 2018, 25 patients with locally recurrent HNSTS after surgery and external beam radiotherapy were enrolled. All the patients successfully underwent CT-guided 125I seed implantation. The primary end points included the objective response rate (ORR) and local progression-free survival (LPFS). The secondary end points were survival (OS) and safety profiles. RESULTS: After 125I seed implantation, the ORR was 76.0%. The 1-, 3-, and 5-year LPFS rates were 65.6%, 34.4%, and 22.9%, respectively, with the median LPFS of 16.0 months. The 1-, 3-, and 5-year OS rates were 70.8%, 46.6%, and 34.0%, respectively, with the median OS of 28.0 months. Furthermore, univariate analyses showed that the recurrent T stage and histological grade were prognostic factors of LPFS, whereas only the histological grade was a predictor of OS. The major adverse events were skin/mucosal toxicities, which were generally of lower grade (≤Grade 2) and were well tolerated. CONCLUSIONS: Radioactive 125I seed implantation could be an effective and safe alternative treatment for locally recurrent HNSTS after failure of surgery and radiotherapy. Recurrent T stage and histological grade were the main factors influencing the efficacy.