RESUMEN
Statistical correlations and predictive values were calculated for 330 gastrointestinal biopsies and tissues, of which 248 were from the stomach from 115 patients in this retrospective study, which graded 10 inflammatory and 14 morphological mucosal and submucosal abnormalities and compared them with the presence of Helicobacter pylori. Analysis revealed that 78 (31.5%) of the 248 stomach biopsies and tissues showed H. pylori, and 21 (8.5%) had non-Helicobacter-like bacteria, such as rods and cocci. Inflammatory components had high correlations, with specimens containing polymorphonuclear leukocytes (PMNs) showing high specificities and predictive values for a positive test, whereas the chronic inflammatory components had high sensitivities and predictive values for a negative test. Positive morphological correlations existed for mucus depletion, degeneration, regeneration, and ulceration, but intestinal metaplasia and adenocarcinoma had negative correlations. The antrum was most commonly infected, suggesting that intact healthy antral morphology and the neutral mucin in the surface epithelial cells represents the optimal environment for infection. Also, 8.5% of the gastric biopsies and tissues showed non-Helicobacter bacteria associated with inflammation, thus raising the question of colonization versus pathogenesis.
Asunto(s)
Sistema Digestivo/microbiología , Gastroenteritis/microbiología , Helicobacter pylori/aislamiento & purificación , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Gastroenteritis/inmunología , Humanos , Masculino , Persona de Mediana Edad , Membrana Mucosa/microbiología , Neutrófilos , Valor Predictivo de las Pruebas , Estudios RetrospectivosRESUMEN
Corticosteroid treatment of acute pancreatitis has recently been advocated by clinicians. The effectiveness of steroids in the prevention of pancreatitis was studied in the model of ethionine pancreatitis in rabbits. A group of 20 rabbits received ethionine for 6 days. Methyl prednisolone succinate was also given to half of the group for a period of 6 days. Animals were killed on the 7th day; enzyme determinations were done; tissues from the pancreas and liver were obtained, coded, and read as unknown by the pathologist; and tissue damage categorized. Corticosteroid treatment was associated with greater elevation of serum amylase and other enzymes. Light microscopic examination of pancreas and liver revealed no apparent beneficial effect from corticosteroid treatment. The experiment was repeated with special stains being made of liver and pancreas, and electron microscopic studies of five animals in each group was done. Light microscopy showed little difference in cellular damage between the two groups. Electron microscopy revealed less apparent damage in the steroid treated (methyl prednisolone succinate) animals than controls. Steroids may provide minimal protection on a subcellular level from ethionine pancreatitis.
Asunto(s)
Corticoesteroides/uso terapéutico , Pancreatitis/tratamiento farmacológico , Enfermedad Aguda , Animales , Etionina , Hígado/efectos de los fármacos , Hígado/ultraestructura , Masculino , Hemisuccinato de Metilprednisolona/uso terapéutico , Páncreas/efectos de los fármacos , Páncreas/ultraestructura , Pancreatitis/inducido químicamente , Pancreatitis/patología , ConejosAsunto(s)
Muerte Súbita/inducido químicamente , Fenotiazinas/efectos adversos , Choque Cardiogénico/inducido químicamente , Adulto , Arritmias Cardíacas/inducido químicamente , Femenino , Humanos , Masculino , Persona de Mediana Edad , Fenotiazinas/administración & dosificación , Choque Cardiogénico/mortalidadRESUMEN
Beta-3 thienylalanine, an inhibitor of zymogen formation, was studied in the experimental model of ethionine pancreatitis in the rabbit. Beta-3TA pretreated and nonpretreated rabbits were given ethionine for six days and controls were given chow only. Animals were killed and serum amylase values determined. Pancreatic tissue was studied by light and electron microscopy. Beta-3TA pretreated rabbits on ethionine showed normal amylase values, while those receiving only ethionine showed high values. Microscopic examination showed severe pancreatitis in the nonpretreated group but only mild vacuolization of cells in the Beta-3TA pretreated animals. Electron microscopy demonstrated integrity of rough endoplasmic reticulum in pretreated animals and severe distortion of cytoplasmic organelles in nonpretreated animals.
Asunto(s)
Alanina/farmacología , Etionina , Pancreatitis/prevención & control , Amilasas/sangre , Animales , Citoplasma , Retículo Endoplásmico , Etionina/administración & dosificación , Masculino , Necrosis , Pancreatitis/inducido químicamente , Pancreatitis/enzimología , Pancreatitis/patología , ConejosRESUMEN
Was aspiration a cause of lung metastases from basal cell carcinoma? We compared our case to prior reported cases with metastases to the lung attributable to aspiration and considered a prior experimental model. We are convinced we have another case of aspiration metastases from basal cell carcinoma, and hereby report "the 92nd known case."