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BACKGROUND: Severe acute pancreatitis (SAP) and obstructive jaundice (OJ) are frequent recurring diseases that bring about huge threat to human health. Some reports have demonstrated that Salviae miltiorrhizae can protect multiple organs of SAP and OJ model animals or patients, but their related mechanisms were not clear. In this study, we observed the effects of Salvia miltiorrhizae injection on apoptosis and NF-κB expression in kidney and explored the protective effect and mechanism of Salvia miltiorrhizae on the kidney of SAP or OJ rats. The results obtained will provide a theoretical basis for clinical application of Salvia miltiorrhizae. MATERIAL AND METHODS: A total of 288 rats were used for SAP -and OJ-associated experiments. The mortality rates of rats, the contents of serum BUN and CREA, the expression levels of Bax, NF-κB proteins and the apoptosis index were observed, respectively. RESULTS: The pathological changes in the kidney of SAP or OJ rats in treated group were mitigated to varying degrees. At 6 and 12 hours after operation in SAP rats or on 21 and 28 days after operation in OJ rats, the contents of serum CREA in treated group were significantly lower than those in model control group; At 3 and 6 hours after operation, the staining intensity of Bax protein of kidney in treated group was significantly lower than that in model control group; on 14 days after operation, the apoptosis index in the kidney of OJ rats in treated group was significantly lower than that in model control group. CONCLUSION: Salvia miltiorrhizae can exert protective effects on the kidney of SAP and OJ rats.
Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Ictericia Obstructiva/tratamiento farmacológico , Enfermedades Renales/prevención & control , Riñón/efectos de los fármacos , Pancreatitis/tratamiento farmacológico , Fitoterapia , Salvia miltiorrhiza , Enfermedad Aguda , Animales , Medicamentos Herbarios Chinos/farmacología , Ictericia Obstructiva/metabolismo , Ictericia Obstructiva/patología , Riñón/metabolismo , Riñón/patología , Enfermedades Renales/etiología , Enfermedades Renales/metabolismo , Enfermedades Renales/patología , Masculino , FN-kappa B/metabolismo , Pancreatitis/metabolismo , Pancreatitis/patología , Sustancias Protectoras/farmacología , Sustancias Protectoras/uso terapéutico , Ratas Sprague-Dawley , Proteína X Asociada a bcl-2/metabolismoRESUMEN
Objective To evaluate the role of endoscopic ultrasonography in the diagnosis and preoperative staging of rectum carcinoma. Methods Fifty-seven patients with rectum carcinoma were performed with preoperative endoscopy and endoscopic ultrasonography. And the staging results of endoscopic ultrasonography were compared to that of postoperative pathological assessment. Result Compared with the pathological staging, the endoscopic ultrasonography staging accuracy rate was 78.9% (45/57),and lymph node metastasis accuracy rate was 73.7% (42/57). Conclusion Endoscopic ultrasonography is effective in diagnosing and preoperative staging of rectum carcinoma.
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700 mL/min).Conclusion The CLh-s could be correlated with operation complications,and be considered as an effective supplement to evaluate hepatic functional reserve when combined with ICGR15 and Child-Pugh classification. It could be used to evaluate liver functional reserve more effectively and reliably.