Asunto(s)
Tamizaje Masivo/métodos , Melanoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , SuizaRESUMEN
We report on a patient with AIDS who developed erythema nodosum, an association that has not previously been reported. Extensive clinical and laboratory investigations disclosed no obvious origin of erythema nodosum apart from HIV infection with disseminated Kaposi sarcoma.
Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/complicaciones , Eritema Nudoso/complicaciones , Sarcoma de Kaposi/complicaciones , Adulto , Eritema Nudoso/patología , Humanos , MasculinoAsunto(s)
Enfermedades de la Uña/etiología , Psoriasis/complicaciones , Administración Tópica , Corticoesteroides/uso terapéutico , Ciclosporina/uso terapéutico , Fluorouracilo/uso terapéutico , Humanos , Enfermedades de la Uña/tratamiento farmacológico , Enfermedades de la Uña/radioterapia , Uñas/anatomía & histología , Terapia PUVA , Fotoquimioterapia , Psoriasis/tratamiento farmacológico , Psoriasis/radioterapia , Retinoides/uso terapéuticoRESUMEN
Inherited deficiencies of classical pathway complement components are rare and associated with autoimmune diseases and with increased susceptibility to bacterial infections. We report the clinical evolution and studies of the complement system in a 17-year-old female patient of Swiss origin presenting with systemic lupus erythematosus (malar rash, photosensitivity, leukopenia and antinuclear antibodies), in whom the hemolytically active second complement component (C2) was less than 10% of the normal value and antigenic C2 was not detectable. Linkage studies showed that the patient is HLA-A25, B18 positive and has the slow factor B allotype BfS. Further immunological assessment revealed low IgG4 concentrations in the patient, who had the G2M(23) allotype. The asymptomatic first degree family members had half-normal C2 levels compatible with a heterozygous state of C2 deficiency. Therapy with hydroxychloroquine for 17 months and topical sunscreen preparations produced marked clinical improvement. During the 4 years of follow-up, the patient has been well and shown only an abnormal titer of antinuclear antibodies. No infections were observed. To the best of our knowledge, 99 cases of homozygous C2 deficiency have been described so far and are discussed here.
Asunto(s)
Complemento C2/deficiencia , Síndromes de Inmunodeficiencia/complicaciones , Lupus Eritematoso Sistémico/complicaciones , Adolescente , Complemento C2/genética , Femenino , Antígenos HLA-A/aislamiento & purificación , Antígenos HLA-B/aislamiento & purificación , Antígeno HLA-B18 , Homocigoto , Humanos , Síndromes de Inmunodeficiencia/genética , Lupus Eritematoso Sistémico/inmunologíaRESUMEN
A case of senile erythroderma with serum hyper-IgE is presented. It is comparable to 8 cases previously described by Japanese authors.
Asunto(s)
Dermatitis Exfoliativa/complicaciones , Hipergammaglobulinemia/complicaciones , Inmunoglobulina E/análisis , Anciano , Dermatitis Exfoliativa/inmunología , Dermatitis Exfoliativa/patología , Humanos , Masculino , Piel/patologíaRESUMEN
The treatment of condyloma acuminatum may be long and tiresome owing to frequent recurrences, and the multiple physical or chemical therapies utilized bear witness to the difficulties often encountered in trying to eradicate the lesions. CO2 laser is a therapeutic alternative with some advantages, such as minimal peripheral thermal necrosis with a lower risk of scar or stricture, haemostasis and perhaps sterilizing effect. Between 1985 and 1987, 69 patients (58 men and 11 women; mean age 29 years) treated with CO2 laser and followed up for at least 6 months without recurrence entered our study. All patients had multiple lesions located in the genital region in 32 cases, in the anal region in 22 cases and in both the genital and anal regions in 15 cases. The majority of patients (85%) had been referred to us owing to failure of previous treatments. We used the CO2 laser coupled with a hand-piece, working by continuous emission, with a power of 300 to 800 watts/sq.cm. Superficial vaporization of the area around the condyloma was systematically performed. Seventy-seven percent of the patients were treated under local anaesthesia. In 16 patients with intra-anal or profuse ano-genital lesions the first vaporization was carried out under general anaesthesia. Twenty-two patients (32%) were cured in one session and 19 (28%) in two sessions. Twenty-eight patients had several recurrences requiring repeated treatments (3 to 5 in 17 cases, 6 to 10 in 10 cases, 31 in 1 case) over a 2 to 17 months' period. No major complications, notably scarring, were observed.(ABSTRACT TRUNCATED AT 250 WORDS)