RESUMEN

Rotaviruses (RVs) are an important cause of severe gastroenteritis in children. It has been found that RV may recognize the histo-blood group antigens (HBGAs) as ligands or receptors and bind HBGAs in a type-dependent manner. In this study, we investigated the binding specificity of VP8* proteins from human rotaviruses (RV) that are prevalent in China including genotypes P[4], P[6], and P[8]. Through the saliva- and oligosaccharide-based binding assays, we found that the VP8* proteins of P[4] and P[8] RV showed similar reactivity with the Leb and H type 1 antigens, while P[6] RV weakly bound the Leb antigen. These findings may facilitate further research into RV host specificity and vaccine development.

Asunto(s)

Antígenos Virales/metabolismo , Antígenos de Grupos Sanguíneos/metabolismo , Rotavirus/genética , Rotavirus/metabolismo , Adulto , Animales , Antígenos Virales/genética , Antígenos de Grupos Sanguíneos/genética , Niño , Femenino , Gastroenteritis/sangre , Gastroenteritis/virología , Genotipo , Humanos , Datos de Secuencia Molecular , Unión Proteica , Proteínas de Unión al ARN/metabolismo , Conejos , Rotavirus/inmunología , Infecciones por Rotavirus/sangre , Saliva/metabolismo , Saliva/virología , Proteínas no Estructurales Virales/metabolismo