RESUMEN
STUDY QUESTION: How does a history of dramatic weight loss linked to bariatric surgery impact IVF outcomes? SUMMARY ANSWER: Women with a history of bariatric surgery who had undergone IVF had a comparable cumulative live birth rate (CLBR) to non-operated patients of the same BMI after the first IVF cycle. WHAT IS KNOWN ALREADY: In the current context of increasing prevalence of obesity in women of reproductive age, weight loss induced by bariatric surgery has been shown to improve spontaneous fertility in obese women. However, little is known on the clinical benefit of bariatric surgery in obese infertile women undergoing IVF. STUDY DESIGN, SIZE, DURATION: This exploratory retrospective multicenter cohort study was conducted in 10 287 IVF/ICSI cycles performed between 2012 and 2016. We compared the outcome of the first IVF cycle in women with a history of bariatric surgery to two age-matched groups composed of non-operated women matched on the post-operative BMI of cases, and non-operated severely obese women. PARTICIPANTS/MATERIALS, SETTING, METHODS: The three exposure groups of age-matched women undergoing their first IVF cycle were compared: Group 1: 83 women with a history of bariatric surgery (exposure, mean BMI 28.9 kg/m2); Group 2: 166 non-operated women (non-exposed to bariatric surgery, mean BMI = 28.8 kg/m2) with a similar BMI to Group 1 at the time of IVF treatment; and Group 3: 83 non-operated severely obese women (non-exposed to bariatric surgery, mean BMI = 37.7 kg/m2). The main outcome measure was the CLBR. Secondary outcomes were the number of mature oocytes retrieved and embryos obtained, implantation and miscarriage rates, live birth rate per transfer as well as birthweight. MAIN RESULTS AND THE ROLE OF CHANCE: No significant difference in CLBR between the operated Group 1 patients and the two non-operated Groups 2 and 3 was observed (22.9%, 25.9%, and 12.0%, in Groups 1, 2 and 3, respectively). No significant difference in average number of mature oocytes and embryos obtained was observed among the three groups. The implantation rates were not different between Groups 1 and 2 (13.8% versus 13.7%), and although lower (6.9%) in obese women of Group 3, this difference was not statistically significant. Miscarriage rates in Groups 1, 2 and 3 were 38.7%, 35.8% and 56.5%, respectively (P = 0.256). Live birth rate per transfer in obese patients was significantly lower compared to the other two groups (20%, 18%, 9.3%, respectively, in Groups 1, 2 and 3, P = 0.0167). Multivariate analysis revealed that a 1-unit lower BMI increased the chances of live birth by 9%. In operated women, a significantly smaller weight for gestational age was observed in newborns of Group 1 compared to Group 3 (P = 0.04). LIMITATIONS, REASONS FOR CAUTION: This study was conducted in France and nearly all patients were Caucasian, questioning the generalizability of the results in other countries and ethnicities. Moreover, 950 women per group would be needed to achieve a properly powered study in order to detect a significant improvement in live birth rate after bariatric surgery as compared to infertile obese women. WIDER IMPLICATIONS OF THE FINDINGS: These data fuel the debate on the importance of pluridisciplinary care of infertile obese women, and advocate for further discussion on whether bariatric surgery should be proposed in severely obese infertile women before IVF. However, in light of the present results, infertile women with a history of bariatric surgery can be reassured that surgery-induced dramatic weight loss has no significant impact on IVF prognosis. STUDY FUNDING/COMPETING INTEREST(S): This work was supported by unrestricted grants from FINOX-Gédéon Richter and FERRING Pharmaceuticals awarded to the ART center of the Clinique Mathilde to fund the data collection and the statistical analysis. There are no conflicts of interest to declare. TRIAL REGISTRATION NUMBER: NCT02884258.
Asunto(s)
Cirugía Bariátrica , Infertilidad Femenina , Tasa de Natalidad , Estudios de Cohortes , Femenino , Fertilización In Vitro , Francia , Humanos , Recién Nacido , Infertilidad Femenina/terapia , Nacimiento Vivo , Embarazo , Índice de Embarazo , Estudios Retrospectivos , Inyecciones de Esperma IntracitoplasmáticasRESUMEN
OBJECTIVE: To compare maternal and perinatal outcome according to gestational age at delivery and length of latency period in a group of patients with preterm premature rupture of membranes. To propose and evaluate an antenatal protocol of home care in a selected group of them. PATIENTS AND METHODS: Inclusion criteria was a delivery in our maternity related to a rupture of membranes prior to 37 week's gestation. Expectant management was applied. Home care management was proposed for patients hospitalised at least 5 days and meeting strict criteria. Maternal-fetal clinical monitoring was performed daily and biological and ultrasound monitoring weekly until 37 or 38 week's gestation. RESULTS: We included 222 patients. There was a significant increase in perinatal complications for neonates before 36 week's gestation. Maternal and perinatal outcomes were not influenced by the latency period. In the overall patients, 44 were hospitalised at least 5 days and 9 could return at home. It seems that there was no difference concerning maternal and fetal complications between home care and hospitalized patients. DISCUSSION AND CONCLUSION: In preterm premature rupture of membranes after 34 week's gestation, monitored expectant management can reduce prematurity complications without increasing infectious complications. After an initial hospitalization, for a small proportion of them, home care seems possible without increasing maternal and fetal morbidity.
Asunto(s)
Rotura Prematura de Membranas Fetales/terapia , Edad Gestacional , Femenino , Monitoreo Fetal , Servicios de Atención de Salud a Domicilio , Hospitalización , Humanos , Embarazo , Resultado del Embarazo , Ultrasonografía PrenatalRESUMEN
Is it possible to safely avoid weekend oocyte retrievals and embryo transfers? It is possible to safely avoid Sunday oocyte retrieval and embryo transfers during GnRH agonist or antagonist cycles, to avoid oocyte retrievals 2 days seem also possible by delaying or advancing hCG administration in both analogs cycles but it is more difficult to avoid embryo transfers during two days. In intra uterine insemination programs, it is possible to avoid ovulation monitoring and inseminations by the use of GnRH antagonists. In IVF programs, ovulation monitoring could be avoid on weekends but the risk of ovarian hyperstimulation would exists in case of polycystic ovary or polycystic like ovary.
Asunto(s)
Transferencia de Embrión/métodos , Oocitos , Técnicas Reproductivas Asistidas , Recolección de Tejidos y Órganos/métodos , Gonadotropina Coriónica/administración & dosificación , Femenino , Fertilización In Vitro , Hormona Liberadora de Gonadotropina/agonistas , Hormona Liberadora de Gonadotropina/antagonistas & inhibidores , Humanos , Síndrome de Hiperestimulación Ovárica/epidemiología , Embarazo , Factores de Riesgo , Factores de TiempoRESUMEN
Oocyte donation is offered to patients with premature ovarian failure to achieve pregnancy when no other assisted reproductive technology is possible. Some clinical and biological factors have been identified for influencing the outcome of oocyte donation cycles. Embryo implantation depends on embryo quality, method for the embryo transfer, and endometrial differentiation. In our center, the oocyte recipients receive for the endometrial preparatory cycle the same treatment that for the patients undergoing frozen embryos transfers, with good clinical pregnancy rates, about 35% per transfer. Estrogen and progesterone supplementation with GnRH agonist down regulation are used in synchronized protocols or for frozen embryos transfers. The synchronization between recipient's endometrium and donor's ovarian stimulation is very restrictive. Nowadays, the oocytes vitrification lithens the oocyte donation process: the endometrial preparation has a limited duration and is well controlled, and embryos that are transferred are all fresh embryos.
Asunto(s)
Endometrio/fisiología , Infertilidad Femenina/terapia , Donación de Oocito , Insuficiencia Ovárica Primaria/complicaciones , Gonadotropina Coriónica/administración & dosificación , Criopreservación , Implantación del Embrión/fisiología , Transferencia de Embrión/métodos , Estradiol/administración & dosificación , Femenino , Fertilización In Vitro , Hormona Liberadora de Gonadotropina/agonistas , Humanos , Infertilidad Femenina/etiología , Ciclo Menstrual/efectos de los fármacos , Ciclo Menstrual/fisiología , Oocitos/fisiología , Embarazo , Progesterona/administración & dosificaciónRESUMEN
OBJECTIVE: To evaluate the results of controlled ovarian hyperstimulation (COH) for IVF in patients with low anti-Müllerian hormone (AMH) and normal basal follicle stimulating hormone (FSH) and Estradiol levels (≤50 pg/mL). PATIENTS AND METHODS: A retrospective cohort study including 704 patients for whom AMH and FSH levels (measured between days 3 and 5 of the menstrual cycle) were available, is performed in the IVF center at the Sèvres Hospital (France). Three groups are designed and analyzed: group 1 with AMH less or equal to 2 ng/mL and FSH less or equal to 10 mUI/mL (study group), Group 2 with AMH greater than 2 ng/mL and FSH less or equal to 10 mUI/mL (control group) and Group 3 with AMH less or equal to 2 ng/mL and FSH greater than 10 mUI/mL (group with decreased ovarian reserve). RESULTS: IVF outcome for patients from the study group is significantly worse than that of the second but not than that of the third group. In the first group, the number of retrieved oocytes, the number of total obtained embryos, the clinical pregnancy rate and the live birth rate are significantly lower than in the second group; moreover, there are more cancelled cycles because of poor response in the first group. There is no difference with the third group. DISCUSSION AND CONCLUSIONS: This study shows that women with a low baseline AMH have a similar response to COH to the poor responders patients with a decreased ovarian reserve revealed by an elevated FSH level. Thus, when a woman undergoing IVF cycle presents a low AMH, she might be considered as a poor responder patient regardless of the FSH level and, although the clinical pregnancy rate is not so disappointing (18%), the couple should be informed of a higher risk of cycle cancellation.
Asunto(s)
Hormona Antimülleriana/sangre , Estradiol/sangre , Fertilización In Vitro , Hormona Folículo Estimulante/sangre , Inducción de la Ovulación , Adulto , Tasa de Natalidad , Femenino , Humanos , Recuperación del Oocito , Embarazo , Índice de Embarazo , Pronóstico , Estudios RetrospectivosRESUMEN
The surgical approach has been a long-lasting option for ovulation restoration in patients presenting with polycystic ovarian syndrome. It consists of ovarian drilling with monopolar, bipolar energy or laser through laparoscopic or vaginal hydrolaparoscopic route. It is intended to be used as a second line therapy as an alternative to gonadotropins in patients with resistance or failure after clomiphene citrate. The results in terms of ovulation restoration and live births make it an attractive alternative with less complications such as multiple pregnancies and ovarian hyperstimulation syndrome.