RESUMEN

Triterpene 2,6-dideoxy-alpha-L-arabino-hexopyranosides were synthesized by the glycosylation of oleanane triterpene alcohols with L-rhamnal acetate in the presence of cationite KU-2-8 and lithium bromide. 2,6-Dideoxy-alpha-L-arabino-hexopyranosides of allobetulin and methyl glycyrrhetinate showed pronounced antiulcerous activity; the latter also stimulated reparative skin regeneration in rats and was effective as a hepatoprotectant.

Asunto(s)

Antiulcerosos/síntesis química , Glicósidos/síntesis química , Ramnosa/análogos & derivados , Triterpenos/síntesis química , Animales , Antiulcerosos/farmacología , Bromuros , Tetracloruro de Carbono , Resinas de Intercambio Iónico , Compuestos de Litio , Hígado/efectos de los fármacos , Ratas , Piel/efectos de los fármacos , Triterpenos/farmacología