RESUMEN
There were presented results of the study directed to disclosure of malignant cell changes criterion in cases of oral mucous membrane leukoplakia with different degrees of neoplastic transformation according to WHO-2005 classification of squamous intraepithelial neoplasia (SIN). With the help of immunohistochemical method proliferation in different layers of oral mucous membrane epithelium was evaluated. It was established that most important for diagnostics was the correspondence of proliferating cells in parabasal and basal epithelium layers. Figure less than 1 was corresponding to normal epithelium and SIN1, between 1 and 2 was corresponding to SIN2, 2 and more was characteristic itoSIN3.
Asunto(s)
Biomarcadores de Tumor/análisis , Carcinoma de Células Escamosas/patología , Transformación Celular Neoplásica/patología , Antígeno Ki-67/análisis , Leucoplasia/patología , Neoplasias de la Boca/patología , Adulto , Carcinoma de Células Escamosas/clasificación , Transformación Celular Neoplásica/clasificación , Diagnóstico Diferencial , Femenino , Humanos , Inmunohistoquímica , Leucoplasia/clasificación , Masculino , Neoplasias de la Boca/clasificaciónRESUMEN
Pathology is a science describing the common regularities of pathological processes underlying disease development. Today pathology is defined as a theoretical science, which is at the same time closely connected to clinical practice. This paper reviews the history of research activities of Laboratory of Pathology of Central Institute of Stomatology. New methods have always been used at the laboratory; today it is histochemistry, radioisotope method (specifically histoautoradiography), and electron microscopy (including cytochemistry). Many-year research activities of the laboratory confirm the significance and perspectiveness of basic studies in dentistry, which are of priority importance for the development of theoretical dentistry and for solving the pressing problems in clinical practice.