RESUMEN
This review focuses on the recent advances in functions of spectrins in non-erythroid cells. We discuss new data concerning the commonly known role of the spectrin-based skeleton in control of membrane organization, stability and shape, and tethering protein mosaics to the cellular motors and to all major filament systems. Particular effort has been undertaken to highlight recent advances linking spectrin to cell signaling phenomena and its participation in signal transduction pathways in many cell types.
Asunto(s)
Citoesqueleto/metabolismo , Transducción de Señal , Espectrina/metabolismo , Animales , Proteínas de Caenorhabditis elegans/genética , Proteínas de Caenorhabditis elegans/metabolismo , Adhesión Celular , Proteínas de Ciclo Celular/metabolismo , Proteínas de Drosophila/genética , Proteínas de Drosophila/metabolismo , Humanos , Microdominios de Membrana/metabolismo , Ratones , Isoformas de Proteínas/genética , Isoformas de Proteínas/metabolismo , Procesamiento Proteico-Postraduccional , Espectrina/genéticaAsunto(s)
Anaplasma phagocytophilum/aislamiento & purificación , Animales Salvajes/microbiología , Ehrlichiosis/veterinaria , Ixodes/microbiología , Rumiantes/microbiología , Anaplasma phagocytophilum/genética , Animales , Sangre/microbiología , Análisis por Conglomerados , ADN Bacteriano/química , ADN Bacteriano/genética , ADN Ribosómico/química , ADN Ribosómico/genética , Ehrlichiosis/epidemiología , Ehrlichiosis/microbiología , Femenino , Masculino , Datos de Secuencia Molecular , Filogenia , Polonia/epidemiología , ARN Ribosómico 16S/genética , Análisis de Secuencia de ADNRESUMEN
Saccharomyces cerevisiae mutants acidifying glucose medium containing bromocresol purple were shown to excrete protons when placed in unbuffered water in the absence of any external carbon source. The mutants belong to 16 different complementation groups. Most of them do not grow on glycerol and the excreted protons are associated to particular sets of organic anions such as citrate, aconitate, succinate, fumarate or malate. These novel types of respiratory mutations seem to be located in genes operating in the Krebs or glyoxylate cycle.